SCHEMBL2222784

SCHEMBL2222784

CN1CCN(c2cncc(N)c2N)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 2/20 0.50
KDM4E B2RXH2 4/20 0.46
MAPT P10636 4/20 0.46
GAA P10253 2/20 0.46
PTK2B Q14289 2/20 0.46
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
RECQL P46063 1/20 0.46
HRH4 Q9H3N8 3/20 0.45
ALDH1A1 P00352 3/20 0.45
POLB P06746 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
RAD52 P43351 1/20 0.41
HSD17B10 Q99714 1/20 0.41
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
ESR2 Q92731 1/20 0.40
NCF1 P14598 1/20 0.40
CYP3A4 P08684 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15301290 0.82 KEAP1 (0.48) KDM4EMAPTGAAMAPK1HTT
SCHEMBL2221075 0.78 MAPT (0.46) KDM4EMAPTGAAMAPK1HTT
SCHEMBL16039371 0.76 ADRA2C (0.58) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL15770645 0.76 MAPT (0.63) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL15301678 0.76 MAPT (0.49) KDM4EMAPTMAPK1HTTALDH1A1
SCHEMBL16040218 0.73 ADRA2C (0.53) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL15770662 0.73 ADRA2C (0.49) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL15770667 0.73 HRH4 (0.44) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL31172405 0.72 ADRA2C (0.72) ADRA2CKDM4EMAPTGAAPTK2B
SCHEMBL1509507 0.72 ADRA2C (0.72) ADRA2CKDM4EMAPTGAAPTK2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BIOSPLICE THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF MED-PATHWAYS II LIMITED (VG) 2024-04-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof BIOSPLICE THERAPEUTICS, INC. (US) 2023-07-11 US disclosed
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2023-01-19 US disclosed
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF TENARX, INC. 2023-01-19 US disclosed
EP-3915988-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BioSplice Therapeutics, Inc. (US) 2021-12-01 EP disclosed
EP-3915988-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF BioSplice Therapeutics, Inc. (US) 2021-12-01 EP disclosed
EP-3284744-B1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED LLC (US) 2021-05-05 EP disclosed
US-8450340-B2 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2013-05-28 US disclosed
US-8450340-B2 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2013-05-28 US disclosed
US-8450340-B2 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof SAMUMED, LLC (US) 2013-05-28 US disclosed
CN-102821607-A 1H-pyrazolo [3,4-b ] pyridines and therapeutic uses thereof SAMUMED LLC 2012-12-12 CN disclosed
EP-2515655-A1 1H-PYRAZOLO[3,4-BETA]PYRIDINES AND THERAPEUTIC USES THEREOF Samumed, LLC (US) 2012-10-31 EP disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-08-04 US disclosed
WO-2011084486-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-07-14 WO disclosed
WO-2011084486-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF EPITHERIX, LLC (US) 2011-07-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190290-A1 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF BRCA1, THPO, PDXK ADRA2C 1341/4885KDM4E 1972/4885MAPT 2756/4885
US-11697649-B2 Indazole inhibitors of the Wnt signal pathway and therapeutic uses thereof WNT1, WNT3, WNT3A ADRA2C 2587/4885KDM4E 3982/4885MAPT 154/4885
US-20230013144-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A ADRA2C 2587/4885KDM4E 3982/4885MAPT 154/4885
US-20240116927-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A ADRA2C 2587/4885KDM4E 3982/4885MAPT 154/4885
US-20260116878-A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A ADRA2C 456/4885KDM4E 4516/4885MAPT 1206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.