Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874864 | 0.84 | LMNA (0.45) | MAPK1SMN1; SMN2LMNAL3MBTL1KMT2A | |
| SCHEMBL220752 | 0.72 | SIGMAR1 (0.51) | MAPK1SMN1; SMN2LMNAALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL5358583 | 0.71 | KMT2A (0.53) | MAPK1SMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL3873216 | 0.70 | MAPK1 (0.52) | MAPK1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL222335 | 0.69 | F10 (0.67) | F10MAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL221423 | 0.69 | ADRA1D (0.55) | — | |
| SCHEMBL221386 | 0.69 | F10 (0.74) | F10MAPK1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL223131 | 0.68 | F10 (0.66) | F10MAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL6345018 | 0.68 | SIGMAR1 (0.60) | MAPK1SMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL7774100 | 0.68 | F10 (0.52) | F10MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088925-B2 | low molecular weight factor Xa specific blood clotting inhibitors; less side effects; 5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide; thromboembolic diseases or restenosis; antithrombotic agents | SANOFI-AVENTIS (FR) | 2012-01-03 | — | — | US | claimed |
| US-8088925-B2 | low molecular weight factor Xa specific blood clotting inhibitors; less side effects; 5-Chloro-thiophene-2-carboxylic acid [2-(1-isopropyl-piperidin-4-ylsulfamoyl)-ethyl]-amide; thromboembolic diseases or restenosis; antithrombotic agents | SANOFI-AVENTIS (FR) | 2012-01-03 | — | — | US | disclosed |