SCHEMBL2224688

SCHEMBL2224688

NC1=c2ccccc2=NC1(N)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 4/20 0.34
BACE2 Q9Y5Z0 2/20 0.34
REN P00797 1/20 0.32
APP P05067 1/20 0.32
PNMT P11086 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21192543 0.98 BACE1 (0.33) BACE1BACE2RENAPPPNMT
Hydrochloric Acid SCHEMBL14576582 0.98 BACE1 (0.33) BACE1BACE2RENAPPPNMT
SCHEMBL11790557 0.75 BACE1 (0.33) BACE1BACE2
SCHEMBL11264366 0.60 LMNA (0.38) BACE1BACE2RENAPPPNMT
SCHEMBL4266501 0.60 MAOA (0.33) BACE1BACE2RENAPPPNMT
SCHEMBL216066 0.60 LMNA (0.35) BACE1BACE2
SCHEMBL5607855 0.59 BACE1 (0.33) BACE1BACE2RENAPP
SCHEMBL5536641 0.59 BACE1 (0.33) BACE1BACE2RENAPP
SCHEMBL27683781 0.57 BACE1 (0.37) BACE1BACE2RENAPPPNMT
SCHEMBL3969821 0.57 BACE1 (0.32) BACE1BACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114790442-A Method for regulating osteogenic differentiation and apoptosis of bone marrow mesenchymal stem cells by using SNHG5 徐州医科大学 2022-07-26 CN claimed
CN-118516374-A Application of garlic AsWRKY transcription factor in improving alliin content in garlic callus 江苏师范大学 2024-08-20 CN disclosed
CN-117210480-A Nucleotide sequences expressing exosome-anchored proteins for use as vaccines 国家高等卫生院 2023-12-12 CN disclosed
CN-116783210-A Nkd2 as target for treating renal fibrosis 亚琛工业大学 2023-09-19 CN disclosed
US-11559571-B2 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine ISTITUTO SUPERIORS DI SANITÀ (IT) 2023-01-24 US disclosed
CN-114790442-A Method for regulating osteogenic differentiation and apoptosis of bone marrow mesenchymal stem cells by using SNHG5 徐州医科大学 2022-07-26 CN disclosed
EP-3049056-B2 ANTIFUNGAL TOPICAL COMPOSITION AND METHODS OF TREATMENT BLUEBERRY THERAPEUTICS LTD (GB) 2022-06-01 EP disclosed
US-20220133640-A1 COMPOSITION AND METHODS OF TREATMENT BLUEBERRY THERAPEUTICS LTD (GB) 2022-05-05 US disclosed
US-11185511-B2 Antifungal topical composition and methods of treatment BLUEBERRY THERAPEUTICS LIMITED (GB) 2021-11-30 US disclosed
EP-3022225-B1 TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES UNIV TEXAS (US) 2021-09-29 EP disclosed
EP-0960203-A1 MAMMALIAN CHK1 EFFECTOR CELL-CYCLE CHECKPOINT PROTEIN KINASE MATERIALS AND METHODS ICOS CORPORATION (US) 1999-12-01 EP disclosed
US-5910568-A GENETICALLY ENGINEERED SYNTHETIC POLYPEPTIDE THAT IS INVOLVED RESTORING THE JOINING CAPACITY OF SEMEN AND OOCYTE; CONTRACEPTIVES; FERTILITY TREATMENTS THE PENN STATE RESEARCH FOUNDATION (US) 1999-06-08 US disclosed
WO-1999011795-A1 MAMMALIAN CHK1 EFFECTOR CELL-CYCLE CHECKPOINT PROTEIN KINASE MATERIALS AND METHODS ICOS CORPORATION (US) 1999-03-11 WO disclosed
EP-0900276-A1 NOVEL CYCLIN-SELECTIVE UBIQUITIN CARRIER POLYPEPTIDES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1999-03-10 EP disclosed
EP-0647271-B1 GENE FOR ATAXIA-TELANGIECTASIA COMPLEMENTATION GROUP D (ATDC) UNIV CALIFORNIA (US) 1999-01-20 EP disclosed
EP-0876610-A1 A METHOD AND USE OF POLYPEPTIDE IN SPERM-EGG BINDING TO ENHANCE OR DECREASE FERTILITY THE PENN STATE RESEARCH FOUNDATION (US) 1998-11-11 EP disclosed
WO-1997037027-A1 NOVEL CYCLIN-SELECTIVE UBIQUITIN CARRIER POLYPEPTIDES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1997-10-09 WO disclosed
WO-1997025620-A1 A METHOD AND USE OF POLYPEPTIDE IN SPERM-EGG BINDING TO ENHANCE OR DECREASE FERTILITY THE PENN STATE RESEARCH FOUNDATION (US) 1997-07-17 WO disclosed
EP-0647271-A1 GENE FOR ATAXIA-TELANGIECTASIA COMPLEMENTATION GROUP D (ATDC) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-04-12 EP disclosed
WO-1994000572-A2 GENE FOR ATAXIA-TELANGIECTASIA COMPLEMENTATION GROUP D (ATDC) THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1994-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220133640-A1 COMPOSITION AND METHODS OF TREATMENT POLR1C, PIK3C3, DPM1 BACE1 4225/4885BACE2 4218/4885REN 3862/4885
US-11185511-B2 Antifungal topical composition and methods of treatment DPM1, POLR1C, TUBB3 BACE1 2879/4885BACE2 1644/4885REN 4817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.