Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256799 | 0.91 | RAB9A (0.47) | LMNARAB9ANPC1THRBTAS1R3 | |
| SCHEMBL22256805 | 0.91 | ALOX15 (0.47) | LMNAKMT2AALOX15 | |
| SCHEMBL25958314 | 0.89 | FLT1 (0.41) | LMNARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL22256819 | 0.89 | RAB9A (0.50) | LMNARAB9ANPC1THRBTAS1R3 | |
| SCHEMBL22939773 | 0.83 | LMNA (0.56) | LMNARAB9ANPC1THRBTAS1R3 | |
| SCHEMBL22256824 | 0.83 | ALOX15 (0.47) | LMNAKMT2AALOX15 | |
| SCHEMBL22256811 | 0.83 | RAB9A (0.52) | LMNARAB9ANPC1HSD17B10HTT | |
| SCHEMBL22256808 | 0.82 | HSD17B10 (0.47) | LMNARAB9ANPC1THRBTAS1R3 | |
| SCHEMBL22256807 | 0.82 | KDM4E (0.43) | LMNARAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22256785 | 0.81 | RAB9A (0.47) | LMNARAB9ANPC1THRBTAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. | 2023-08-10 | — | — | US | disclosed |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | EMPIRICO INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11116778-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | EMPIRICO INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210030772-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. | 2021-02-04 | — | — | US | disclosed |
| WO-2020150265-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. (US) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | ALOX15, ALOX5, ALOX15B | LMNA 2806/4885RAB9A 4106/4885NPC1 2279/4885 |
| US-20210030772-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | ALOX15, ALOX5, ALOX15B | LMNA 2806/4885RAB9A 4106/4885NPC1 2279/4885 |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | ALOX15, ALOX5, ALOX15B | LMNA 2806/4885RAB9A 4106/4885NPC1 2279/4885 |
| US-11116778-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | ALOX15, ALOX5, ALOX15B | LMNA 2806/4885RAB9A 4106/4885NPC1 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.