Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25958318 | 0.89 | FLT1 (0.41) | LMNARAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL22256802 | 0.82 | LMNA (0.48) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22256799 | 0.82 | RAB9A (0.47) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22939284 | 0.82 | LMNA (0.52) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22256823 | 0.82 | ALOX15 (0.51) | KMT2AALOX15 | |
| SCHEMBL22256819 | 0.81 | RAB9A (0.50) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22939366 | 0.80 | KDM4E (0.47) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22256785 | 0.79 | RAB9A (0.47) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22256811 | 0.78 | RAB9A (0.52) | HSD17B10KDM4ERXFP1LMNARAB9A | |
| SCHEMBL22256788 | 0.76 | RAB9A (0.49) | HSD17B10KDM4ERXFP1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. | 2023-08-10 | — | — | US | disclosed |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | EMPIRICO INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11116778-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | EMPIRICO INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210030772-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. | 2021-02-04 | — | — | US | disclosed |
| WO-2020150265-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. (US) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | ALOX15, ALOX5, ALOX15B | HSD17B10 127/4885KDM4E 1449/4885RXFP1 3948/4885 |
| US-20210030772-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | ALOX15, ALOX5, ALOX15B | HSD17B10 127/4885KDM4E 1449/4885RXFP1 3948/4885 |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | ALOX15, ALOX5, ALOX15B | HSD17B10 127/4885KDM4E 1449/4885RXFP1 3948/4885 |
| US-11116778-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | ALOX15, ALOX5, ALOX15B | HSD17B10 127/4885KDM4E 1449/4885RXFP1 3948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.