SCHEMBL2226074

SCHEMBL2226074

COc1ccc(C(CC(=O)O)CC(=O)O)cc1

nearest known ligand 0.68

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.68
FFAR1 O14842 8/20 0.66
FNTA P49354 2/20 0.61
FNTB P49356 2/20 0.61
KMT2A Q03164 2/20 0.56
ATM Q13315 1/20 0.56
POLB P06746 1/20 0.55
ITGB3 P05106 3/20 0.50
ITGAV P06756 3/20 0.50
LDHA P00338 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5340895 0.92 L3MBTL1 (0.59) L3MBTL1FFAR1FNTAFNTBKMT2A
SCHEMBL4453571 0.91 FFAR1 (0.78) L3MBTL1FFAR1FNTAFNTBKMT2A
SCHEMBL10200947 0.90 GABBR2 (0.64) L3MBTL1FFAR1FNTAFNTBKMT2A
SCHEMBL6484578 0.86 FFAR1 (0.66) L3MBTL1FFAR1KMT2AATMLDHA
SCHEMBL28854188 0.85 FFAR1 (0.59) L3MBTL1FFAR1FNTAFNTBKMT2A
SCHEMBL27829876 0.85 ALDH1A1 (0.62) L3MBTL1FFAR1FNTAFNTBLDHA
SCHEMBL15782118 0.84 AKR1C3 (0.62) L3MBTL1FFAR1
SCHEMBL16624890 0.84 L3MBTL1 (0.81) L3MBTL1FFAR1FNTAFNTBATM
SCHEMBL16249736 0.83 GABBR2 (0.61) L3MBTL1FFAR1FNTAFNTBKMT2A
SCHEMBL4478662 0.83 FFAR1 (0.56) L3MBTL1FFAR1KMT2AATMLDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011085445-A1 FLOTATION REAGENTS TEEBEE HOLDINGS PTY LTD (AU) 2011-07-21 WO claimed
EP-4709719-A1 5-CYANO-1H-IMIDAZOLE-2-CARBOXAMIDE COMPOUNDS AS CSF1R INHIBITORS Modulo Bio, Inc. (US) 2026-03-18 EP disclosed
US-12551490-B2 Heterocyclic modulators of lipid synthesis SAGIMET BIOSCIENCES INC. (US) 2026-02-17 US disclosed
WO-2024254440-A1 5-CYANO-1H-IMIDAZOLE-2-CARBOXAMIDE COMPOUNDS AS CSF1R INHIBITORS MODULO BIO, INC. (US) 2024-12-12 WO disclosed
US-20240400552-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2024-12-05 US disclosed
CN-117550943-A Based on CO 2 Method for participating in controllable synthesis of polycarboxylic acid compounds 四川大学 2024-02-13 CN disclosed
US-20230405016-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS SAGIMET BIOSCIENCES INC. 2023-12-21 US disclosed
CN-117247317-A Based on CO 2 Method for synthesizing dicarboxylic acid/tricarboxylic acid compound 四川大学 2023-12-19 CN disclosed
CN-116139138-A Heterocyclic modulators of lipid synthesis 3-V生物科学股份有限公司 2023-05-23 CN disclosed
US-11622968-B2 Heterocyclic modulators of lipid synthesis SAGIMET BIOSCIENCES INC. (US) 2023-04-11 US disclosed
US-4323511-A Steroid derivatives and their use in radioimmunoassays E. R. SQUIBB & SONS, INC. (US) 1982-04-06 US disclosed
EP-0005558-B1 STEROID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN RADIOIMMUNOASSAYS E.R. Squibb & Sons, Inc. (US) 1982-01-27 EP disclosed
EP-0005834-B1 VITAMIN B-12 DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN RADIOIMMUNOASSAYS E.R. Squibb & Sons, Inc. (US) 1981-10-14 EP disclosed
US-4248783-A Steroids having a 3-(4-hydroxyphenyl)pentanedioic acid monohydrazide substituent E. R. SQUIBB & SONS, INC. (US) 1981-02-03 US disclosed
US-4243608-A 3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs E. R. SQUIBB & SONS, INC. (US) 1981-01-06 US disclosed
US-4230621-A TRACERS, HYDROXYPHENYLGLUTARIC ACID DERIVATIVES E. R. SQUIBB & SONS, INC. (US) 1980-10-28 US disclosed
US-4221725-A CHEMICAL INTERMEDIATE E. R. SQUIBB & SONS, INC. (US) 1980-09-09 US disclosed
US-4209614-A Vitamin B12 derivative suitable for radiolabeling E. R. SQUIBB & SONS, INC. (US) 1980-06-24 US disclosed
EP-0005834-A1 Vitamin B-12 derivatives, process for their preparation and their use in radioimmunoassays E.R. Squibb & Sons, Inc. (US) 1979-12-12 EP disclosed
EP-0005558-A1 Steroid derivatives, process for their preparation and their use in radioimmunoassays E.R. Squibb & Sons, Inc. (US) 1979-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230405016-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 L3MBTL1 2557/4885FFAR1 125/4885FNTA 133/4885
US-20240400552-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS FASN, FADS1, FADS2 L3MBTL1 2516/4885FFAR1 149/4885FNTA 117/4885
US-12551490-B2 Heterocyclic modulators of lipid synthesis FASN, FADS1, FADS2 L3MBTL1 2521/4885FFAR1 25/4885FNTA 446/4885
US-11622968-B2 Heterocyclic modulators of lipid synthesis FASN, FADS1, SCD L3MBTL1 2485/4885FFAR1 133/4885FNTA 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.