Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434485 | 0.83 | TSHR (0.44) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL4950787 | 0.83 | TSHR (0.44) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL28812803 | 0.83 | TSHR (0.44) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL2211256 | 0.79 | MAPT (0.54) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL27969503 | 0.76 | TSHR (0.46) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL31299616 | 0.75 | TSHR (0.53) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL4954406 | 0.72 | MAPT (0.44) | TSHRALDH1A1MAPTILKRAB9A | |
| SCHEMBL2873389 | 0.71 | ALDH1A1 (0.48) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL31299652 | 0.71 | TSHR (0.49) | TSHRALDH1A1CYP1A2MAPTILK | |
| SCHEMBL6816550 | 0.69 | ALDH1A1 (0.59) | ALDH1A1CYP1A2MAPTILKHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11716992-B2 | 5A5B6C tricyclic spirolactone derivative, preparation method therefor and use thereof | NANKAI UNIVERSITY (CN) | 2023-08-08 | — | — | US | disclosed |
| US-11166460-B2 | α-amino acrylate microbicide, and preparation method therefor and uses thereof | NANKAI UNIVERSITY (CN) | 2021-11-09 | — | — | US | disclosed |
| US-20210289783-A1 | 5A5B6C Tricyclic spirolactone derivative, preparation method therefor and use thereof | UNIV NANKAI (CN) | 2021-09-23 | — | — | US | disclosed |
| US-20200236935-A1 | a-Amino Acrylate microbicide, and preparation method therefor and uses thereof | UNIV NANKAI (CN) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210289783-A1 | 5A5B6C Tricyclic spirolactone derivative, preparation method therefor and use thereof | CYP51A1, CYP4B1, CYP7B1 | TSHR 2683/4885ALDH1A1 137/4885CYP1A2 53/4885 |
| US-20200236935-A1 | a-Amino Acrylate microbicide, and preparation method therefor and uses thereof | AASDHPPT, ACE, ADA | TSHR 3945/4885ALDH1A1 322/4885CYP1A2 1844/4885 |
| US-11716992-B2 | 5A5B6C tricyclic spirolactone derivative, preparation method therefor and use thereof | CYP51A1, CYP4B1, CYP7B1 | TSHR 2683/4885ALDH1A1 137/4885CYP1A2 53/4885 |
| US-11166460-B2 | α-amino acrylate microbicide, and preparation method therefor and uses thereof | ACE, AASDHPPT, DDT | TSHR 3937/4885ALDH1A1 253/4885CYP1A2 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.