SCHEMBL2228477

SCHEMBL2228477

CCN(CC)Cc1ccc(-c2[c]cccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 3/20 0.58
CNR2 P34972 1/20 0.41
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
KDM4E B2RXH2 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
LTA4H P09960 1/20 0.38
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
OPRD1 P41143 1/20 0.37
AOC3 Q16853 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1371196 0.80 TP53 (0.44) KDM4ETAAR1MAPK1L3MBTL1
SCHEMBL1368894 0.77 LPL (0.37) KDM4E
SCHEMBL1775198 0.77 TRPA1 (0.44) TAAR1TSHR
SCHEMBL12680476 0.75 HRH3 (1.00) HRH3CNR2HDAC8HDAC6TAAR1
SCHEMBL1370764 0.75 HSD11B1 (0.47) KDM4ETSHR
SCHEMBL27647893 0.74 TDP1 (0.48)
SCHEMBL8081767 0.73 HSD11B1 (0.49) HRH3KDM4ETSHR
SCHEMBL8723594 0.73 HRH3 (0.44) HRH3CNR2HDAC8HDAC6KDM4E
SCHEMBL9029706 0.73 TAAR1 (0.54) HRH3KDM4ETAAR1LTA4H
SCHEMBL6609575 0.73 TSHR (0.44) LTA4HTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1598053-B1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres OREAL (FR) 2006-12-20 EP claimed
EP-1598053-A1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres L'OREAL (FR) 2005-11-23 EP claimed
US-20050251928-A1 Method for stripping artificial color from keratin fibers L'OREAL (FR) 2005-11-17 US claimed
US-20230165771-A1 PROCESS FOR TREATING KERATIN FIBERS USING PARTICULAR AMINO ACIDS IN HIGH CONCENTRATION L'OREAL (FR) 2023-06-01 US disclosed
EP-4171490-A1 PROCESS FOR TREATING KERATIN FIBERS USING PARTICULAR AMINO ACIDS IN HIGH CONCENTRATION L'OREAL (FR) 2023-05-03 EP disclosed
CN-115996701-A Method for treating keratin fibres using a high concentration of a specific amino acid 莱雅公司 2023-04-21 CN disclosed
WO-2022003040-A1 PROCESS FOR TREATING KERATIN FIBERS USING PARTICULAR AMINO ACIDS IN HIGH CONCENTRATION L'OREAL (FR) 2022-01-06 WO disclosed
WO-2017025244-A1 COSMETIC PROCESS FOR TREATING KERATIN MATERIALS L'OREAL (FR) 2017-02-16 WO disclosed
WO-2017018498-A1 COMPOSITION, PROCESS, METHOD AND USE FOR KERATIN FIBERS L'OREAL (FR) 2017-02-02 WO disclosed
WO-2016098870-A1 PROCESS FOR TREATING KERATIN FIBERS TECHNICAL FIELD L'OREAL (FR) 2016-06-23 WO disclosed
WO-2016076437-A1 COMPOSITION FOR KERATIN FIBERS L'OREAL (FR) 2016-05-19 WO disclosed
WO-2011089985-A1 COSMETIC COMPOSITION FOR KERATIN FIBERS L'OREAL (FR) 2011-07-28 WO disclosed
EP-1598053-B1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres OREAL (FR) 2006-12-20 EP disclosed
EP-1598053-A1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres L'OREAL (FR) 2005-11-23 EP disclosed
US-20050251928-A1 Method for stripping artificial color from keratin fibers L'OREAL (FR) 2005-11-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230165771-A1 PROCESS FOR TREATING KERATIN FIBERS USING PARTICULAR AMINO ACIDS IN HIGH CONCENTRATION KRT18, CKAP4, VIM HRH3 575/4885CNR2 4863/4885HDAC8 3008/4885
US-20050251928-A1 Method for stripping artificial color from keratin fibers KRT18, DSG1, JUP HRH3 294/4885CNR2 4282/4885HDAC8 590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.