Water

Water

SCHEMBL2230233

Nc1nc(N)nc(N)n1.Nc1nc(N)nc(N)n1.O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A known ✓ P29274 3/20 0.40
ADORA1 known ✓ P30542 3/20 0.40
ADORA3 known ✓ P0DMS8 1/20 0.40
ADORA2B known ✓ P29275 1/20 0.40
HTR2B known ✓ P41595 1/20 0.31
PDE4D known ✓ Q08499 1/20 0.31
CASP1 P29466 1/20 0.47
LMNA P02545 2/20 0.42
POLB P06746 1/20 0.40
CYP1A2 P05177 1/20 0.38
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
KDM4E B2RXH2 3/20 0.33
ALOX15 P16050 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
HSP90AB1 P08238 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL6686404 1.00 CASP1 (0.47) CASP1LMNAADORA2AADORA1POLB
Water SCHEMBL845969 1.00 CASP1 (0.47) CASP1LMNAADORA2AADORA1POLB
Water SCHEMBL8139598 0.95 CASP1 (0.44) CASP1LMNAADORA2AADORA1POLB
SCHEMBL29485005 0.94
SCHEMBL9579151 0.94 CASP1 (0.50) CASP1LMNAADORA2AADORA1POLB
SCHEMBL25853 0.94
SCHEMBL8465809 0.94 CASP1 (0.50) CASP1LMNAADORA2AADORA1POLB
SCHEMBL29900242 0.94
SCHEMBL9583239 0.94 CASP1 (0.50) CASP1LMNAADORA2AADORA1POLB
SCHEMBL175612 0.94 CASP1 (0.50) CASP1LMNAADORA2AADORA1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107189733-B Polyol ether toughened and modified melamine-formaldehyde-urea copolycondensation adhesive, and preparation method and application thereof 南京林业大学 2020-12-22 CN claimed
CN-110885289-A Pipeline reaction synthesis method of p-nitroaniline 乐平市景顺实业有限公司 2020-03-17 CN claimed
US-9988518-B2 Chlorine-resistant crosslinkable polyolefin compositions and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2018-06-05 US claimed
EP-2563827-B1 CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2017-06-21 EP claimed
US-20150132518-A1 CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. 2015-05-14 US claimed
US-8962718-B2 Chlorine-resistant crosslinkable polyolefin compositions and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-02-24 US claimed
US-20130127961-A1 COMPOSITE MATERIAL AND PROCESS FOR PRODUCING IT PFLEIDERER HOLZWERKSTOFFE GMBH (DE) 2013-05-23 US claimed
EP-2563827-A1 CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM Momentive Performance Materials Inc. (US) 2013-03-06 EP claimed
WO-2011139635-A1 CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-11-10 WO claimed
US-20110259464-A1 CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2011-10-27 US claimed
EP-0628180-B1 PLIABLE, AQUEOUS PROCESSABLE, PHOTOIMAGEABLE PERMANENT COATINGS FOR PRINTED CIRCUITS DU PONT (US) 1998-09-16 EP claimed
US-5536620-A ACRYLIC, POLYURETHANE ACRYLATE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-07-16 US claimed
EP-0628180-A1 PLIABLE, AQUEOUS PROCESSABLE, PHOTOIMAGEABLE PERMANENT COATINGS FOR PRINTED CIRCUITS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-12-14 EP claimed
WO-1993017368-A1 PLIABLE, AQUEOUS PROCESSABLE, PHOTOIMAGEABLE PERMANENT COATINGS FOR PRINTED CIRCUITS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-09-02 WO claimed
WO-2024146756-A1 METHOD FOR PRODUCING A LAMINATE COMPRISING AT LEAST ONE KRAFT PAPER LAYER AND AT LEAST ONE OTHER PAPER LAYER SWISS KRONO Tec AG (CH) 2024-07-11 WO disclosed
US-20240034840-A1 HYDROPHOBIZING AGENT HAVING A PERMANENT EFFECT RUDOLF GMBH (DE) 2024-02-01 US disclosed
EP-4298154-A1 HYDROPHOBIZING AGENT HAVING A PERMANENT EFFECT Rudolf GmbH (DE) 2024-01-03 EP disclosed
US-4119599-A Cathodic electrocoating compositions containing acid-functional aminoplast and flexibilized, epoxy-free, aminated resin SCM CORPORATION (US) 1978-10-10 US disclosed
US-4066525-A CATHODIC ELECTROCOATING PROCESS SCM CORPORATION (US) 1978-01-03 US disclosed
US-3972677-A Process for the preparation of discharge effects on dyeings or prints made with disperse dyes on flat-surface textile structures of synthetic fibers HOECHST AKTIENGESELLSCHAFT (DT) 1976-08-03 US disclosed