Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | PARL | Q9H300 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118462 | 0.81 | L3MBTL1 (0.50) | ACHEALDH1A1HTTMMP2LMNA | |
| SCHEMBL7118457 | 0.81 | L3MBTL1 (0.50) | ACHEALDH1A1HTTMMP2LMNA | |
| SCHEMBL21465092 | 0.81 | L3MBTL1 (0.50) | ACHEALDH1A1HTTMMP2LMNA | |
| SCHEMBL14738049 | 0.81 | ACHE (0.65) | ACHEPARLALDH1A1HSD11B1SMN1; SMN2 | |
| SCHEMBL7122701 | 0.81 | ACHE (0.65) | ACHEPARLALDH1A1HSD11B1SMN1; SMN2 | |
| SCHEMBL7125327 | 0.80 | TRPA1 (0.48) | ALDH1A1SMN1; SMN2MAPTMMP2TDP1 | |
| SCHEMBL7125321 | 0.80 | TRPA1 (0.48) | ALDH1A1SMN1; SMN2MAPTMMP2TDP1 | |
| SCHEMBL7129560 | 0.79 | TSHR (0.65) | ACHEALDH1A1MMP2L3MBTL1 | |
| SCHEMBL7129555 | 0.79 | TSHR (0.65) | ACHEALDH1A1MMP2L3MBTL1 | |
| SCHEMBL7121012 | 0.77 | HSD11B1 (0.56) | ALDH1A1HSD11B1HTTMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | ACHE 4863/4885PARL 3506/4885ALDH1A1 3564/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | ACHE 4745/4885PARL 3944/4885ALDH1A1 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.