SCHEMBL223109

SCHEMBL223109

[c]1c2c(nc3ccccc13)CCNC2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.36
CYP3A4 P08684 2/20 0.36
PNMT P11086 1/20 0.35
CD44 P16070 1/20 0.35
MAOB P27338 1/20 0.35
PDCD1 Q15116 2/20 0.35
CD274 Q9NZQ7 2/20 0.35
PARP1 P09874 1/20 0.35
TNKS2 Q9H2K2 1/20 0.35
PARP2 Q9UGN5 1/20 0.35
HTR2C P28335 5/20 0.34
HTR2A P28223 2/20 0.33
HTR2B P41595 2/20 0.33
APEX1 P27695 1/20 0.32
KDM4E B2RXH2 2/20 0.32
HTR5A P47898 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
NR2E1 Q9Y466 1/20 0.32
BCHE P06276 2/20 0.31
ACHE P22303 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL222039 0.87 PARP1 (0.37) MAPTCYP3A4PNMTCD44MAOB
SCHEMBL223760 0.85 TDP1 (0.30) MAPTCYP3A4KDM4EBCHEACHE
SCHEMBL4440098 0.77 POLB (0.35) CYP3A4PDCD1CD274HTR2CHTR2A
SCHEMBL4909847 0.76 BCHE (0.45) CYP3A4KDM4EBCHEACHECACNB4
SCHEMBL1532144 0.76 BCHE (0.45) CYP3A4KDM4EBCHEACHECACNB4
SCHEMBL4464318 0.75 BCHE (0.46) CYP3A4KDM4EBCHEACHECACNB4
SCHEMBL6312249 0.73 HTR2C (0.47) MAPTCYP3A4PNMTCD44MAOB
SCHEMBL6313436 0.70 HTR2C (0.48) MAPTCYP3A4PARP1TNKS2PARP2
SCHEMBL30751773 0.67 CYP3A4 (0.55) MAPTCYP3A4PNMTCD44MAOB
SCHEMBL2401358 0.67 CYP3A4 (0.55) MAPTCYP3A4PNMTCD44MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2024-05-16 US disclosed
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS BIOND BIOLOGICS LTD. (IL) 2024-05-09 US disclosed
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-01-25 US disclosed
US-20230201201-A1 COMPOSITION FOR USE IN THE TREATMENT OF APOL1-ASSOCIATED DISEASE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2023-06-29 US disclosed
US-20230124527-A1 NANOPARTICLES FOR CHEMIRESISTOR SENSORS NANOSCENT LTD. (IL) 2023-04-20 US disclosed
US-20230104413-A1 NANOPARTICLES FOR CHEMIRESISTOR SENSORS NANOSCENT LTD. (IL) 2023-04-06 US disclosed
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 US disclosed
EP-4004127-A1 COATING COMPOSITIONS WITH POLYSILOXANE-MODIFIED CARBON NANOPARTICLE Valfre' di Bonzo, Roberto (CH) 2022-06-01 EP disclosed
US-11307158-B1 Nanoparticles for chemiresistor sensors NANOSCENT LTD. (IL) 2022-04-19 US disclosed
WO-2021014430-A1 COATING COMPOSITIONS WITH POLYSILOXANE-MODIFIED CARBON NANOPARTICLE VALFRE' DI BONZO, Roberto (CH) 2021-01-28 WO disclosed
WO-2009128918-A1 COMBINATION THERAPY USING A SOLUBLE HYALURONIDASE AND A BISPHOSPHONATE HALOZYME, INC. (US) 2009-10-22 WO disclosed
US-7582794-B2 Process for the preparation of substituted 2-(phenoxymethyl)benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-09-01 US disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed
WO-2009009117-A2 CHEMOENZYMATIC PROCESSES FOR PREPARATION OF LEVETIRACETAM BIOVERDANT, INC. (US) 2009-01-15 WO disclosed
EP-1699748-B1 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI AVENTIS DEUTSCHLAND (DE) 2008-10-15 EP disclosed
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-09-20 US disclosed
US-7238835-B2 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-07-03 US disclosed
EP-1699748-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS Sanofi-Aventis Deutschland GmbH (DE) 2006-09-13 EP disclosed
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-08-04 US disclosed
WO-2005061427-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230201201-A1 COMPOSITION FOR USE IN THE TREATMENT OF APOL1-ASSOCIATED DISEASE APOL1, APOB, LIPA MAPT 689/4885CYP3A4 4439/4885PNMT 3826/4885
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS CYP2B6, CYP1B1, CYP4B1 MAPT 4159/4885CYP3A4 24/4885PNMT 1543/4885
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS LCAT, CD47, PHOSPHO1 MAPT 913/4885CYP3A4 4794/4885PNMT 890/4885
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS ACTB, CHERP, EEA1 MAPT 627/4885CYP3A4 4851/4885PNMT 4517/4885
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids CYP2B6, CYP1B1, CYP4B1 MAPT 4159/4885CYP3A4 24/4885PNMT 1543/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG MAPT 3495/4885CYP3A4 585/4885PNMT 1602/4885
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING IGF2BP1, IGF2BP2, IGF2BP3 MAPT 2590/4885CYP3A4 4862/4885PNMT 3078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.