Sugi Predict

Sugi Predict / Compounds / SCHEMBL2236638

SCHEMBL2236638

SCHEMBL2236638

O=C(NCCCl)Nc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX1 P07099 5/20 0.62
▸ KDM4E B2RXH2 1/20 0.62
▸ ALDH1A1 P00352 1/20 0.60
▸ HTT P42858 1/20 0.60
▸ SMN1; SMN2 Q16637 3/20 0.59
▸ TP53 P04637 1/20 0.59
▸ TSHR P16473 1/20 0.59
▸ EPHX2 P34913 1/20 0.59
▸ CDK9 P50750 1/20 0.59
▸ CLK4 Q9HAZ1 1/20 0.59
▸ CNR1 P21554 2/20 0.57
▸ HDAC1 Q13547 1/20 0.57
▸ HDAC8 Q9BY41 1/20 0.57
▸ HDAC6 Q9UBN7 1/20 0.57
▸ NPC1 O15118 1/20 0.57
▸ RAB9A P51151 1/20 0.57
▸ MEN1 O00255 2/20 0.55
▸ KMT2A Q03164 2/20 0.55
▸ POLB P06746 1/20 0.55
▸ LMNA P02545 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6687903 0.90 CASR (0.66) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL2234743 0.89 EPHX1 (0.68) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL11051077 0.88 EPHX1 (0.70) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL6689395 0.85 RNF4 (0.68) ALDH1A1HTTSMN1; SMN2CNR1NPC1
SCHEMBL2446111 0.84 EPHX1 (0.77) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL6690096 0.83 MAOA (0.53) ALDH1A1SMN1; SMN2TSHRCNR1NPC1
SCHEMBL10939812 0.83 CNR1 (0.70) KDM4ESMN1; SMN2CNR1NPC1RAB9A
SCHEMBL9547553 0.82 EPHX1 (0.83) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL3513673 0.82 EPHX1 (0.64) EPHX1KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL325607 0.82 EPHX1 (0.64) EPHX1KDM4EALDH1A1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US claimed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US claimed
CN-119161306-A Bicycloacetamide structural compound, preparation method and pharmaceutical application thereof 河南大学 2024-12-20 — — CN disclosed
US-20210163404-A1 NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES UNIVERSITé LAVAL (CA) 2021-06-03 — — US disclosed
WO-2018227300-A1 NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES UNIVERSITé LAVAL (CA) 2018-12-20 — — WO disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
US-9034888-B2 Substituted 2-imidazolidones and analogs UNIVERSITE LAVAL (CA) 2015-05-19 — — US disclosed
EP-2536693-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS Université Laval (CA) 2012-12-26 — — EP disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS UNIVERSITE LAVAL (CA) 2012-12-06 — — US disclosed
US-20090176766-A1 IMIDAZOLIDINONE AND IMIDAZOLIDINETHIONE DERIVATIVES NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2009-07-09 — — US disclosed
WO-2007084435-A2 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2007-07-26 — — WO disclosed
CN-1189466-C New direct chain or cyclic urea, its preparing method and medicinal composition containing them ADIR (FR) 2005-02-16 — — CN disclosed
WO-2004106292-A1 HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH IMOTEP INC. (CA) 2004-12-09 — — WO disclosed
WO-2001047504-A2 β-TUBELIN INHIBITORS AND THEIR USE AGAINST CANCER UNIVERSITé LAVAL (CA) 2001-07-05 — — WO disclosed
CN-1301699-A New direct chain or cyclic urea, its preparing method and medicinal composition containing them ADIR (FR) 2001-07-04 — — CN disclosed
US-4407939-A GELATIN MODIFIED WITH SUCCINIC, PHTHALIC OR TRIMELLITIC ANHYDRIDE POSITIONED BETWEEN FUJI PHOTO FILM CO., LTD. (JP) 1983-10-04 — — US disclosed
US-4059697-A N-(Substituted)aminocarbonyl O,S-dialkyl phosphoramido(di)thioates and method of controlling arthropods ROHM AND HAAS COMPANY (US) 1977-11-22 — — US disclosed
US-4021245-A GELATION DERIVATIVE, SILICIC ACID ANHYDRIDE FUJI PHOTO FILM CO., LTD. (JA) 1977-05-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309777-A1 SUBSTITUTED 2-IMIDAZOLIDONES AND ANALOGS CCNY, RPS4Y1, TPX2 EPHX1 3256/4885KDM4E 429/4885ALDH1A1 1937/4885
US-20210163404-A1 NOVEL UREA COMPOUNDS AND BIOISOSTERES THEREOF AND THEIR USE FOR TREATING INFLAMMATION AND INFLAMMATION-RELATED PATHOLOGIES NOS3, NOS2, CBS EPHX1 1279/4885KDM4E 3250/4885ALDH1A1 1252/4885
US-20090176766-A1 IMIDAZOLIDINONE AND IMIDAZOLIDINETHIONE DERIVATIVES ZC3HAV1, EIF2AK2, ZYX EPHX1 3419/4885KDM4E 2799/4885ALDH1A1 818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.