Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22382328 | 0.94 | KMT2A (0.58) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL3358898 | 0.92 | KMT2A (0.52) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15321361 | 0.91 | HCAR3 (0.68) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15319957 | 0.91 | MAPT (0.66) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15320365 | 0.89 | HCAR3 (0.70) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15319810 | 0.89 | HCAR3 (0.70) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL2027705 | 0.88 | HCAR3 (0.68) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15320045 | 0.88 | HCAR3 (0.68) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15320956 | 0.88 | HCAR3 (0.68) | KMT2AALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL15319505 | 0.88 | HCAR3 (0.68) | KMT2AALDH1A1MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409533-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-12-12 | — | — | US | disclosed |
| CN-113874074-B | HMOX1 inducers | 米托布里奇公司 | 2024-11-01 | — | — | CN | disclosed |
| US-12071433-B2 | HMOX1 inducers | Astellas Engineered Small Molecules US, Incorporated (US) | 2024-08-27 | — | — | US | disclosed |
| US-20240051952-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2024-02-15 | — | — | US | disclosed |
| US-20220177460-A1 | HMOX1 INDUCERS | Astellas Engineered Small Molecules US, Incorporated | 2022-06-09 | — | — | US | disclosed |
| EP-3952990-A1 | HMOX1 INDUCERS | Mitobridge, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| CN-113874074-A | HMOX1 inducers | 米托布里奇公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020210339-A1 | HMOX1 INDUCERS | MITOBRIDGE, INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-10766888-B1 | HMOX1 inducers | MITOBRIDGE INC. (US) | 2020-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766888-B1 | HMOX1 inducers | HMOX1, HMOX2, HMBS | KMT2A 2901/4885ALDH1A1 332/4885MAPT 3846/4885 |
| US-20240409533-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | KMT2A 2901/4885ALDH1A1 332/4885MAPT 3846/4885 |
| US-12071433-B2 | HMOX1 inducers | HMOX1, HMOX2, HMBS | KMT2A 3092/4885ALDH1A1 223/4885MAPT 3756/4885 |
| US-20240051952-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, QSOX1 | KMT2A 4276/4885ALDH1A1 266/4885MAPT 3238/4885 |
| US-20220177460-A1 | HMOX1 INDUCERS | HMOX1, HMOX2, HMBS | KMT2A 3092/4885ALDH1A1 223/4885MAPT 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.