Sugi Predict

Sugi Predict / Compounds / SCHEMBL22389

SCHEMBL22389

SCHEMBL22389

CNC(=O)c1cnc2ccccc2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 1/20 0.65
▸ MGAM O43451 1/20 0.65
▸ HPGDS O60760 3/20 0.62
▸ PSMD14 O00487 1/20 0.58
▸ STAMBP O95630 1/20 0.58
▸ COPS5 Q92905 1/20 0.58
▸ BCAT1 P54687 1/20 0.58
▸ KDR P35968 2/20 0.55
▸ MEN1 O00255 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ CYP1A2 P05177 1/20 0.54
▸ CYP3A4 P08684 1/20 0.54
▸ CCR1 P32246 1/20 0.54
▸ NPC1 O15118 3/20 0.54
▸ RAB9A P51151 3/20 0.54
▸ KDM4E B2RXH2 2/20 0.54
▸ MITF O75030 1/20 0.54
▸ XBP1 P17861 1/20 0.54
▸ PAX8 Q06710 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28901564 0.85 MGAM (0.68) PLK1MGAMHPGDSBCAT1KDR
SCHEMBL2230677 0.85 MGAM (0.67) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL28666318 0.83 MGAM (0.65) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL6237473 0.83 MGAM (0.65) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL12043740 0.83 HPGDS (0.67) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL28087629 0.83 MGAM (0.59) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL20812002 0.83 HPGDS (0.65) MGAMHPGDSBCAT1KDRMEN1
SCHEMBL5161544 0.81 MGAM (0.58) PLK1MGAMHPGDSBCAT1KDR
SCHEMBL5436334 0.81 MGAM (0.58) PLK1MGAMHPGDSBCAT1KDR
SCHEMBL29684771 0.81 MGAM (0.71) MGAMHPGDSBCAT1KDRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8513421-B2 Substituted hydroxamic acids and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2013-08-20 — — US claimed
EP-2569285-A1 BIFUNCTIONAL QUINOLINE DERIVATIVES Gilead Sciences, Inc. (US) 2013-03-20 — — EP claimed
WO-2011143105-A1 BIFUNCTIONAL QUINOLINE DERIVATIVES GILEAD SCIENCES, INC. (US) 2011-11-17 — — WO claimed
CN-115551864-A Substituted tricyclic amides, analogs thereof, and methods of using the same 爱彼特生物制药公司 2022-12-30 — — CN disclosed
US-20220402841-A1 Stilbene Derivative and Method for Preparing Same Ozchela Inc. (KR) 2022-12-22 — — US disclosed
US-20190255009-A1 STILBENE DERIVATIVE AND METHOD FOR PREPARING SAME OZCHELA INC (KR) 2019-08-22 — — US disclosed
US-20190248729-A1 STILBENE DERIVATIVE AND METHOD FOR PREPARING SAME Ozchela Inc. (KR) 2019-08-15 — — US disclosed
US-9775843-B2 Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders Grünenthal GmbH (DE) 2017-10-03 — — US disclosed
US-20170273970-A1 Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders Grünenthal GmbH (DE) 2017-09-28 — — US disclosed
EP-2609085-A1 SUBSTITUTED QUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS Grünenthal GmbH (DE) 2013-07-03 — — EP disclosed
US-8445512-B2 Substituted quinoline-3-carboxamides as KCNQ2/3 modulators GRUENENTHAL GMBH (DE) 2013-05-21 — — US disclosed
US-20090075909-A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds RANBAXY LABORATORIES LIMITED INC. (IN) 2009-03-19 — — US disclosed
US-7432264-B2 Antimicrobial biaryl compounds ISIS PHARMACEUTICALS, INC. (US) 2008-10-07 — — US disclosed
US-7432264-B2 Antimicrobial biaryl compounds ISIS PHARMACEUTICALS, INC. (US) 2008-10-07 — — US disclosed
US-20080153821-A1 Nitrogen-containing 5-membered ring compound TANABE SEIYAKU CO., LTD. 2008-06-26 — — US disclosed
US-7332487-B2 Nitrogen-containing 5-membered ring compound TANABE SEIYAKU CO., LTD. (JP) 2008-02-19 — — US disclosed
EP-0110955-B1 BRAIN-SPECIFIC DRUG DELIVERY UNIV FLORIDA (US) 1995-08-23 — — EP disclosed
US-4540564-A DIHYDROPYRIDINE AND/OR PYRIDINIUM SALT REDOX CARRIER UNIVERSITY OF FLORIDA (US) 1985-09-10 — — US disclosed
EP-0110955-A1 BRAIN-SPECIFIC DRUG DELIVERY. UNIV FLORIDA (US) 1984-06-20 — — EP disclosed
WO-1983003968-A1 BRAIN-SPECIFIC DRUG DELIVERY UNIVERSITY OF FLORIDA (US) 1983-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190255009-A1 STILBENE DERIVATIVE AND METHOD FOR PREPARING SAME HPN, P4HB, FKBP1B PLK1 4033/4885MGAM 2561/4885HPGDS 158/4885
US-20220402841-A1 Stilbene Derivative and Method for Preparing Same FKBP1B, FKBP8, FKBP2 PLK1 4205/4885MGAM 3034/4885HPGDS 282/4885
US-20090075909-A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds HLA-DRB1, IL5, TNF PLK1 4479/4885MGAM 188/4885HPGDS 525/4885
US-20190248729-A1 STILBENE DERIVATIVE AND METHOD FOR PREPARING SAME FKBP1B, FKBP8, FKBP2 PLK1 4205/4885MGAM 3034/4885HPGDS 282/4885
US-20170273970-A1 Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders TSPO, TPMT, HLA-DRB1 PLK1 4620/4885MGAM 1470/4885HPGDS 80/4885
US-20080153821-A1 Nitrogen-containing 5-membered ring compound ALK, SCO2, NPR1 PLK1 4150/4885MGAM 4685/4885HPGDS 4290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.