SCHEMBL22391775

SCHEMBL22391775

O=c1ccc(N2CCNCC2)nn1CCc1ccc(Cl)cc1F

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ HTR2C P28335 13/20 0.52
▸ HTR2A P28223 3/20 0.52
▸ HTR3E A5X5Y0 1/20 0.43
▸ HTR3B O95264 1/20 0.43
▸ HTR3A P46098 1/20 0.43
▸ HTR3D Q70Z44 1/20 0.43
▸ HTR3C Q8WXA8 1/20 0.43
▸ P2RX7 Q99572 1/20 0.39
▸ MCHR1 Q99705 1/20 0.39
▸ TRPA1 O75762 1/20 0.38
▸ HTR2B P41595 2/20 0.38
▸ DPP4 P27487 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30454467 1.00 HTR2C (0.52) HTR2CHTR2AHTR3EHTR3BHTR3A
SCHEMBL22391864 0.77 PTGDR2 (0.44) HTR2CHTR2AHTR2BDPP4
SCHEMBL30454657 0.77 PTGDR2 (0.44) HTR2CHTR2AHTR2BDPP4
SCHEMBL30454533 0.74 GLP1R (0.37) HTR2CHTR2ATRPA1
SCHEMBL29016266 0.72 HTR2C (0.49) HTR2CHTR2AHTR3EHTR3BHTR3A
SCHEMBL22392142 0.72 HTR1A (0.40) HTR2CHTR2AHTR3EHTR3BHTR3A
SCHEMBL30454719 0.72 HTR1A (0.40) HTR2CHTR2AHTR3EHTR3BHTR3A
SCHEMBL20288052 0.70 HTR3A (0.51) HTR2CHTR2AHTR3EHTR3BHTR3A
SCHEMBL13533076 0.69 HTR2C (0.54) HTR2CHTR2AHTR2B
Hydrochloric Acid SCHEMBL28973080 0.69 HTR3A (0.50) HTR2CHTR2AHTR3EHTR3BHTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC (CN) 2026-02-05 — — US disclosed
US-12365670-B2 GLP-IR agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2025-07-22 — — US disclosed
CN-113227068-B GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2023-06-13 — — CN disclosed
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2022-01-27 — — US disclosed
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2022-01-27 — — US disclosed
CN-113227068-A GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2021-08-06 — — CN disclosed
US-10844049-B2 GLP-1R agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2020-11-24 — — US disclosed
US-10844049-B2 GLP-1R agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2020-11-24 — — US disclosed
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2020-09-10 — — US disclosed
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2020-09-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, IAPP HTR2C 1375/4885HTR2A 1546/4885HTR3E 1825/4885
US-10844049-B2 GLP-1R agonists and uses thereof GLP1R, GPR119, GIPR HTR2C 558/4885HTR2A 441/4885HTR3E 453/4885
US-12365670-B2 GLP-IR agonists and uses thereof GLP1R, GPR119, GIPR HTR2C 815/4885HTR2A 638/4885HTR3E 814/4885
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR HTR2C 558/4885HTR2A 441/4885HTR3E 453/4885
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR HTR2C 644/4885HTR2A 474/4885HTR3E 583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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