SCHEMBL22392142

SCHEMBL22392142

O=c1c(N2CCNCC2)cccn1CCc1ccc(Cl)cc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR1A P08908 7/20 0.40
▸ HTR2C P28335 3/20 0.40
▸ HTR2A P28223 3/20 0.40
▸ DRD2 P14416 2/20 0.40
▸ DRD3 P35462 2/20 0.40
▸ DRD4 P21917 1/20 0.40
▸ HTR6 P50406 7/20 0.40
▸ HTR3A P46098 4/20 0.39
▸ CYP1A2 P05177 3/20 0.39
▸ CYP3A4 P08684 3/20 0.39
▸ CYP2D6 P10635 3/20 0.39
▸ CYP2C9 P11712 3/20 0.39
▸ ADRB1 P08588 3/20 0.39
▸ SLC6A4 P31645 3/20 0.39
▸ HTR3E A5X5Y0 2/20 0.39
▸ HTR3B O95264 2/20 0.39
▸ HTR3D Q70Z44 2/20 0.39
▸ HTR3C Q8WXA8 2/20 0.39
▸ HTR2B P41595 2/20 0.39
▸ TP53 P04637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30454719 1.00 HTR1A (0.40) HTR1AHTR2CHTR2ADRD2DRD3
SCHEMBL22391591 0.80 VEGFA (0.44) CYP3A4HTT
SCHEMBL30454430 0.74 GLP1R (0.34) HTR1AHTR2CHTR2ADRD2DRD4
SCHEMBL30455093 0.74 GLP1R (0.34) HTR1AHTR2CHTR2ADRD2DRD4
SCHEMBL30455284 0.73 ALDH1A1 (0.37) CYP3A4SLC6A4HTTSLC6A2
SCHEMBL22391775 0.72 HTR2C (0.52) HTR2CHTR2AHTR3AHTR3EHTR3B
SCHEMBL30454467 0.72 HTR2C (0.52) HTR2CHTR2AHTR3AHTR3EHTR3B
SCHEMBL29772851 0.70 HTR3A (0.55) HTR1AHTR2CHTR2ADRD2DRD3
SCHEMBL234944 0.70 HTR3A (0.55) HTR1AHTR2CHTR2ADRD2DRD3
Hydrochloric Acid SCHEMBL22533692 0.68 HTR3A (0.54) HTR1AHTR2CHTR2ADRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC (CN) 2026-02-05 — — US disclosed
US-12365670-B2 GLP-IR agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2025-07-22 — — US disclosed
CN-113227068-B GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2023-06-13 — — CN disclosed
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2022-01-27 — — US disclosed
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2022-01-27 — — US disclosed
CN-113227068-A GLP-1R agonists and uses thereof 上海齐鲁锐格医药研发有限公司 2021-08-06 — — CN disclosed
US-10844049-B2 GLP-1R agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2020-11-24 — — US disclosed
US-10844049-B2 GLP-1R agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2020-11-24 — — US disclosed
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2020-09-10 — — US disclosed
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF QILU REGOR THERAPEUTICS INC. (CN) 2020-09-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035362-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, IAPP HTR1A 950/4885HTR2C 1375/4885HTR2A 1546/4885
US-10844049-B2 GLP-1R agonists and uses thereof GLP1R, GPR119, GIPR HTR1A 498/4885HTR2C 558/4885HTR2A 441/4885
US-12365670-B2 GLP-IR agonists and uses thereof GLP1R, GPR119, GIPR HTR1A 881/4885HTR2C 815/4885HTR2A 638/4885
US-20200283424-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR HTR1A 498/4885HTR2C 558/4885HTR2A 441/4885
US-20220024901-A1 GLP-1R AGONISTS AND USES THEREOF GLP1R, GPR119, GIPR HTR1A 584/4885HTR2C 644/4885HTR2A 474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback