Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29777621 | 0.80 | CYP2C19 (0.37) | POLBGAATDP1GRM2ALDH1A1 | |
| SCHEMBL29777585 | 0.80 | POLB (0.38) | POLBGAATDP1ALDH1A1HTT | |
| SCHEMBL20939715 | 0.78 | PIK3CD (0.36) | MAP3K14POLBGAATDP1PIK3CD | |
| SCHEMBL20400203 | 0.77 | NLRP3 (0.38) | GAAPKMALDH1A1CYP1A2MAPT | |
| SCHEMBL22421167 | 0.77 | RAB9A (0.46) | POLBGAATDP1GRM2ALDH1A1 | |
| SCHEMBL22421148 | 0.75 | ALDH1A1 (0.33) | MAP3K14ALDH1A1CYP1A2MAPTCYP2C9 | |
| SCHEMBL22421129 | 0.73 | MAP3K14 (0.40) | MAP3K14POLBGAATDP1PIK3CD | |
| SCHEMBL29777626 | 0.68 | PKM (0.35) | PKMALDH1A1CYP1A2HTTLMNA | |
| SCHEMBL14922854 | 0.68 | LMNA (0.30) | POLBPKMLMNA | |
| SCHEMBL29777572 | 0.67 | KDM4E (0.35) | POLBGAATDP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478673-B1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-09-16 | — | — | EP | disclosed |