Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28671519 | 0.82 | CLPP (0.44) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22410754 | 0.79 | P2RX3 (0.51) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22424057 | 0.78 | PNP (0.48) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22424242 | 0.76 | MAPT (0.44) | ALDH1A1POLBHTTTP53GAA | |
| SCHEMBL22424051 | 0.68 | CLPP (0.39) | CLPPALDH1A1POLBHTTTP53 | |
| SCHEMBL22746816 | 0.66 | ALDH1A1 (0.41) | CLPPALDH1A1POLBHTTGAA | |
| SCHEMBL1573104 | 0.65 | PNP (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17491168 | 0.65 | SIGMAR1 (0.71) | ALDH1A1POLBSIGMAR1LMNA | |
| SCHEMBL1573111 | 0.65 | PDE5A (0.51) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9242005 | 0.65 | PNP (0.51) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | disclosed |