SCHEMBL224482

SCHEMBL224482

[CH]1NCCCc2c1[nH]c1ccccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HSD17B10 Q99714 1/20 0.47
HTR2A P28223 1/20 0.45
HTR2C P28335 1/20 0.45
BRD3 Q15059 1/20 0.44
KDM4E B2RXH2 3/20 0.44
HTR5A P47898 1/20 0.44
NISCH Q9Y2I1 1/20 0.44
NR2E1 Q9Y466 1/20 0.44
CYP2C19 P33261 2/20 0.42
TAAR1 Q96RJ0 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
KIF11 P52732 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDR P35968 1/20 0.41
MAPK10 P53779 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL103312 0.89 HTR2A (0.51) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL6504509 0.75 MEN1 (0.50) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL428079 0.75 HSD17B10 (0.50) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL31319181 0.75 MEN1 (0.50) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL224258 0.72 KDM4E (0.46) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL1919190 0.71 HTR2A (0.46) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL28459559 0.70 MEN1 (0.45) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL28465952 0.70 MEN1 (0.45) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL28459535 0.70 MEN1 (0.45) MEN1KMT2AHSD17B10HTR2AHTR2C
SCHEMBL998088 0.69 KDM4E (0.81) MEN1KMT2AHSD17B10HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024134657-A1 PYRROLOPYRIDINE AND PYRROLOPYRIDAZINE BASED COMPOUNDS AND USE THEREOF AS PKR INHIBITORS PROTEKT THERAPEUTICS LTD. (IL) 2024-06-27 WO disclosed
EP-4376837-A1 COMPOUNDS FOR NEUTROPHIL ROS INHIBITION Immunyx Pharma Ltd. (IL) 2024-06-05 EP disclosed
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2024-05-16 US disclosed
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS BIOND BIOLOGICS LTD. (IL) 2024-05-09 US disclosed
CN-117651568-A Intracellular delivery compositions 比昂生物制剂公司 2024-03-05 CN disclosed
EP-4326332-A1 INTRACELLULAR DELIVERY COMPOSITIONS Biond Biologics Ltd. (IL) 2024-02-28 EP disclosed
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-01-25 US disclosed
WO-2023233413-A1 eIF4G1-eIF1 INHIBITORS AND USE THEREOF YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2023-12-07 WO disclosed
US-20230201201-A1 COMPOSITION FOR USE IN THE TREATMENT OF APOL1-ASSOCIATED DISEASE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) 2023-06-29 US disclosed
WO-2023112038-A1 NEUTROPHIL EXOCYTOSIS INHIBITORS IMMUNYX PHARMA LTD. (IL) 2023-06-22 WO disclosed
WO-2009128918-A1 COMBINATION THERAPY USING A SOLUBLE HYALURONIDASE AND A BISPHOSPHONATE HALOZYME, INC. (US) 2009-10-22 WO disclosed
US-7582794-B2 Process for the preparation of substituted 2-(phenoxymethyl)benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-09-01 US disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed
WO-2009009117-A2 CHEMOENZYMATIC PROCESSES FOR PREPARATION OF LEVETIRACETAM BIOVERDANT, INC. (US) 2009-01-15 WO disclosed
EP-1699748-B1 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI AVENTIS DEUTSCHLAND (DE) 2008-10-15 EP disclosed
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-09-20 US disclosed
US-7238835-B2 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2007-07-03 US disclosed
EP-1699748-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS Sanofi-Aventis Deutschland GmbH (DE) 2006-09-13 EP disclosed
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-08-04 US disclosed
WO-2005061427-A2 METHOD FOR THE PRODUCTION OF SUBSTITUTED 2-(PHENOXYMETHYL)-BENZOIC ACIDS SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230201201-A1 COMPOSITION FOR USE IN THE TREATMENT OF APOL1-ASSOCIATED DISEASE APOL1, APOB, LIPA MEN1 1100/4885KMT2A 4245/4885HSD17B10 378/4885
US-20070219395-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-(PHENOXYMETHYL)BENZOIC ACIDS CYP2B6, CYP1B1, CYP4B1 MEN1 415/4885KMT2A 1106/4885HSD17B10 521/4885
US-20240156742-A1 TARGETED MULTIFUNCTIONAL NANOSTRUCTURED LIPID CARRIERS LCAT, CD47, PHOSPHO1 MEN1 762/4885KMT2A 419/4885HSD17B10 1006/4885
US-20240148886-A1 INTRACELLULAR DELIVERY COMPOSITIONS ACTB, CHERP, EEA1 MEN1 2434/4885KMT2A 4267/4885HSD17B10 3810/4885
US-20050171205-A1 Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids CYP2B6, CYP1B1, CYP4B1 MEN1 415/4885KMT2A 1106/4885HSD17B10 521/4885
US-20240025886-A1 INHIBITORS OF IGF2BP1-RNA BINDING IGF2BP1, IGF2BP2, IGF2BP3 MEN1 855/4885KMT2A 1585/4885HSD17B10 2502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.