Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254208 | 1.00 | EPHX2 (0.42) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL9811897 | 1.00 | EPHX2 (0.42) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL2247731 | 0.98 | KMT2A (0.41) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL21167241 | 0.95 | KMT2A (0.41) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL4621861 | 0.91 | KMT2A (0.44) | EPHX2KMT2AALOX15BLMPMP22 | |
| SCHEMBL5323996 | 0.91 | KMT2A (0.44) | EPHX2KMT2AALOX15BLMPMP22 | |
| SCHEMBL29501687 | 0.86 | EPHX2 (0.53) | EPHX2SMN1; SMN2LMNAMMP2MMP9 | |
| SCHEMBL5313119 | 0.83 | SMN1; SMN2 (0.36) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL5313120 | 0.83 | SMN1; SMN2 (0.36) | EPHX2KMT2ASMN1; SMN2ALOX15BLM | |
| SCHEMBL9811947 | 0.83 | ALDH1A1 (0.40) | EPHX2SMN1; SMN2LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
| EP-0154343-B1 | ADSORBENT | Research Development Corporation of Japan (JP) | 1991-06-19 | — | — | EP | disclosed |
| US-4785021-A | OPTICAL RESOLUTION | RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) | 1988-11-15 | — | — | US | disclosed |
| US-4747956-A | CROSSLINKED POLYAMINO ACID | RESEARCH DEVELOPMENT CORPORATION (JP) | 1988-05-31 | — | — | US | disclosed |
| US-4694044-A | Adsorbent | RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0154343-A2 | Adsorbent | Research Development Corporation of Japan (JP) | 1985-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | EPHX2 1904/4885KMT2A 2364/4885SMN1; SMN2 2624/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | EPHX2 1904/4885KMT2A 2364/4885SMN1; SMN2 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.