Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.59 |
| ▸ | HPGDS | O60760 | 6/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245221 | 0.86 | CA2 (0.56) | MMP12HPGDSCA1HDAC2HDAC3 | |
| SCHEMBL3583040 | 0.83 | ADAMTS5 (0.48) | MMP12HDAC2HDAC3HDAC4HDAC1 | |
| SCHEMBL14122491 | 0.81 | MMP12 (0.59) | MMP12HPGDSMMP2MMP8MMP13 | |
| SCHEMBL6868321 | 0.81 | MMP12 (0.59) | MMP12HPGDSMMP2MMP8MMP13 | |
| SCHEMBL2249740 | 0.81 | MMP12 (0.66) | MMP12HPGDSPTPN1CA1CA12 | |
| SCHEMBL2246054 | 0.80 | MMP12 (0.76) | MMP12HPGDSPTPN1CA1CA12 | |
| SCHEMBL2245321 | 0.80 | MMP12 (0.76) | MMP12HPGDSPTPN1CA1CA12 | |
| SCHEMBL2247344 | 0.80 | ADAMTS5 (0.67) | MMP12HPGDSHDAC2HDAC3HDAC4 | |
| SCHEMBL2245488 | 0.79 | HPGDS (0.71) | MMP12HPGDSPTPN1CA1CA12 | |
| SCHEMBL4622966 | 0.78 | MMP12 (0.63) | MMP12HPGDSPTPN1CA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |