Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.56 |
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | FPGS | Q05932 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | GART | P22102 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245207 | 0.86 | MMP12 (0.59) | CA2CA1HDAC2HDAC3HDAC4 | |
| SCHEMBL2249747 | 0.81 | CA2 (0.63) | CA2CA1HDAC1HDAC6MMP12 | |
| SCHEMBL2246061 | 0.80 | CA2 (0.69) | CA2CA1MMP12HPGDSKMT2A | |
| SCHEMBL2245325 | 0.80 | CA2 (0.69) | CA2CA1MMP12HPGDSKMT2A | |
| SCHEMBL27728759 | 0.80 | CA2 (0.59) | CA2CA1MMP12KMT2A | |
| SCHEMBL2245494 | 0.79 | HPGDS (0.65) | CA2CA1HDAC1MMP12HPGDS | |
| SCHEMBL4621821 | 0.78 | CA2 (0.63) | CA2CA1MMP12DHFRKMT2A | |
| SCHEMBL2248811 | 0.78 | CA2 (0.57) | CA2CA1MMP12MRGPRX4KMT2A | |
| SCHEMBL2245609 | 0.78 | CA2 (0.66) | CA2CA1MMP12HPGDSKMT2A | |
| SCHEMBL2249692 | 0.77 | CA2 (0.62) | CA2CA1DHFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | claimed |
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |
| CN-101223130-A | Glutamate aggrecanase inhibitors | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |