Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251027 | 0.90 | CA2 (0.51) | FFAR1FFAR4CA2CA1PTPN1 | |
| SCHEMBL2250678 | 0.90 | MMP12 (0.54) | POLBKMT2AGAAPTGER4PTGER3 | |
| SCHEMBL2250715 | 0.87 | MRGPRX4 (0.51) | POLBKMT2AGAAFFAR1CA2 | |
| SCHEMBL2245262 | 0.87 | MRGPRX4 (0.53) | POLBKMT2AGAACA2ALDH1A1 | |
| SCHEMBL3589157 | 0.83 | KLKB1 (0.50) | PTGER4PTGER3PTGER1PTGER2FFAR1 | |
| SCHEMBL2243990 | 0.82 | DHFR (0.50) | POLBKMT2AGAACA2ALDH1A1 | |
| SCHEMBL2247651 | 0.81 | MRGPRX4 (0.56) | FFAR1FFAR4CA2CA1MRGPRX4 | |
| SCHEMBL3589161 | 0.80 | HSD17B2 (0.45) | KMT2APTGER4PTGER3PTGER1PTGER2 | |
| SCHEMBL2251677 | 0.80 | GPR132 (0.55) | FFAR1CA2ALDH1A1CA1PTPN1 | |
| SCHEMBL2251026 | 0.79 | MMP12 (0.57) | PTGER4PTGER3PTGER1PTGER2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |