Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.49 |
| ▸ | FAAH | O00519 | 5/20 | 0.49 |
| ▸ | CNR2 | P34972 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452699 | 0.89 | FAAH (0.53) | EPHX2FAAHCNR2KMT2AMEN1 | |
| SCHEMBL22453032 | 0.84 | CNR2 (0.47) | EPHX2FAAHCNR2KMT2AMEN1 | |
| SCHEMBL22453561 | 0.79 | CNR2 (0.53) | EPHX2FAAHCNR2KMT2AMEN1 | |
| SCHEMBL22452514 | 0.79 | NPC1 (0.47) | EPHX2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL22452717 | 0.75 | SERPINE1 (0.48) | EPHX2KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL22453323 | 0.73 | FAAH (0.63) | EPHX2FAAHCNR2ALDH1A1MAPT | |
| SCHEMBL22453243 | 0.73 | SERPINE1 (0.50) | EPHX2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL22452816 | 0.72 | FAAH (0.64) | EPHX2FAAHCNR2ALDH1A1MAPT | |
| SCHEMBL22452516 | 0.71 | HIF1A (0.47) | EPHX2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL14503290 | 0.71 | FAAH (0.82) | EPHX2FAAHCNR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |