Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.53 |
| ▸ | FAAH | O00519 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452699 | 0.90 | FAAH (0.53) | CNR2FAAHKMT2AMEN1ATM | |
| SCHEMBL22453032 | 0.86 | CNR2 (0.47) | CNR2FAAHKMT2AMEN1ATM | |
| SCHEMBL22452698 | 0.79 | EPHX2 (0.49) | CNR2FAAHKMT2AMEN1ATM | |
| SCHEMBL22453768 | 0.78 | USP2 (0.42) | CNR2FAAHKMT2AMEN1PKM | |
| SCHEMBL22453489 | 0.75 | KMT2A (0.42) | KMT2AALDH1A1MAPTNPSR1KDM4E | |
| SCHEMBL22452667 | 0.73 | HIF1A (0.44) | KMT2AMEN1NPSR1HTT | |
| SCHEMBL22452673 | 0.73 | PGR (0.50) | KMT2ANPSR1HTT | |
| SCHEMBL14503290 | 0.72 | FAAH (0.82) | CNR2FAAHKMT2AMEN1ATM | |
| SCHEMBL4956421 | 0.72 | KMT2A (0.59) | KMT2AATMALDH1A1MAPTHPGD | |
| SCHEMBL22453481 | 0.72 | PGR (0.46) | CNR2KMT2ANPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |