Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | SLC25A1 | P53007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453477 | 0.92 | LMNA (0.42) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL22452713 | 0.89 | DHODH (0.43) | MEN1KMT2ALMNAALDH1A1CCR2 | |
| SCHEMBL22452725 | 0.88 | MEN1 (0.46) | MEN1KMT2ALMNAMIFSLC25A1 | |
| SCHEMBL22452983 | 0.84 | MEN1 (0.48) | MEN1KMT2ALMNAMIFSLC25A1 | |
| SCHEMBL22452630 | 0.83 | LMNA (0.45) | KMT2ALMNAPOLBALDH1A1TDP1 | |
| SCHEMBL22453074 | 0.82 | PARP1 (0.41) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL22452805 | 0.82 | FABP4 (0.47) | MEN1KMT2ALMNAALDH1A1RECQL | |
| SCHEMBL22453463 | 0.81 | CRHBP (0.39) | MEN1KMT2AALDH1A1TDP1CRHBP | |
| SCHEMBL22453774 | 0.80 | LMNA (0.47) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL22452486 | 0.77 | HIF1A (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |