Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.33 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.33 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453075 | 0.85 | DHODH (0.49) | GRM4HIF1AEPAS1MEN1RAB9A | |
| SCHEMBL22453756 | 0.83 | CNR2 (0.49) | GRM4HIF1AEPAS1MEN1RAB9A | |
| SCHEMBL22452783 | 0.74 | LMNA (0.33) | HIF1AMEN1KMT2A | |
| SCHEMBL22452811 | 0.74 | HIF1A (0.52) | HIF1AEPAS1MEN1KMT2A | |
| SCHEMBL22453327 | 0.73 | ALDH1A1 (0.55) | MEN1RAB9AKMT2A | |
| SCHEMBL22452888 | 0.73 | EPHX2 (0.36) | HIF1AMEN1RAB9AKMT2A | |
| SCHEMBL22452478 | 0.73 | HIF1A (0.40) | HIF1AEPAS1 | |
| SCHEMBL22453205 | 0.72 | MAPT (0.46) | HIF1AEPAS1 | |
| SCHEMBL22452743 | 0.72 | PDE10A (0.45) | HIF1AEPAS1RAB9A | |
| SCHEMBL22453118 | 0.72 | CA12 (0.42) | HIF1AMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |