Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452931 | 0.86 | S100B (0.46) | MAPTALDH1A1KDM4CMEN1KMT2A | |
| SCHEMBL22452587 | 0.82 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4CMEN1KMT2A | |
| SCHEMBL22453522 | 0.81 | DHFR (0.44) | ALDH1A1KDM4CGPR3DHFR | |
| SCHEMBL22453357 | 0.79 | KIF11 (0.41) | ALDH1A1L3MBTL1KDM4EHSD17B10SCN9A | |
| SCHEMBL22681911 | 0.74 | KDM4C (0.40) | MAPTALDH1A1KDM4CMEN1KMT2A | |
| SCHEMBL22452606 | 0.70 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL498377 | 0.69 | ALDH1A1 (0.56) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL9530875 | 0.69 | ALDH1A1 (0.55) | MAPTALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL12021921 | 0.68 | BRD4 (0.40) | MAPTALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL9682 | 0.68 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |