Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452717 | 0.81 | SERPINE1 (0.48) | USP2MAPTHTTGAAMEN1 | |
| SCHEMBL22453561 | 0.78 | CNR2 (0.53) | USP2MAPTALDH1A1HTTMEN1 | |
| SCHEMBL22453777 | 0.74 | EPHX2 (0.58) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL22453343 | 0.73 | SIRT2 (0.54) | ALDH1A1GAAMEN1KMT2APKM | |
| SCHEMBL22453544 | 0.72 | EPHX2 (0.54) | MEN1KMT2ARAB9ANPC1PKM | |
| SCHEMBL22452673 | 0.71 | PGR (0.50) | HTTKMT2ANPC1LMNANPSR1 | |
| SCHEMBL22453243 | 0.71 | SERPINE1 (0.50) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL22452667 | 0.69 | HIF1A (0.44) | HTTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL22453766 | 0.68 | HPGD (0.56) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22453501 | 0.68 | KMT2A (0.45) | MAPTALDH1A1HTTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |