Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PNLIP | P16233 | 10/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453205 | 0.82 | MAPT (0.46) | MAPTALOX15PNLIPGCGR | |
| SCHEMBL22453074 | 0.79 | PARP1 (0.41) | MAPTPNLIPPTGS2MT-CO2TDP1 | |
| SCHEMBL22453760 | 0.77 | RAB9A (0.40) | MAPTPNLIPTOP1MEN1KMT2A | |
| SCHEMBL22453440 | 0.76 | TOP1 (0.39) | MAPTALOX15PNLIPPTGS2TOP1 | |
| SCHEMBL22453597 | 0.74 | MAPT (0.47) | MAPTALOX15PNLIPGCGRPTGS2 | |
| SCHEMBL22453592 | 0.73 | MRGPRX4 (0.53) | MAPTALOX15PNLIPTDP1MEN1 | |
| SCHEMBL22452811 | 0.72 | HIF1A (0.52) | MAPTPNLIPGCGRTDP1MEN1 | |
| SCHEMBL22453480 | 0.72 | MAPT (0.52) | MAPTALOX15PTGS2SIRT2MEN1 | |
| SCHEMBL22452507 | 0.71 | MAPT (0.53) | MAPTALOX15SIRT2MEN1KMT2A | |
| SCHEMBL22453525 | 0.71 | MAPT (0.50) | MAPTALOX15PTGS2SIRT2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |