SCHEMBL22462872

SCHEMBL22462872

CC(C)(C)OC(=O)N1CC(COCc2ccc(C(F)(F)F)cc2F)C1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.41
GPR119 Q8TDV5 1/20 0.41
RORC P51449 1/20 0.41
TACR1 P25103 3/20 0.41
DPP4 P27487 1/20 0.40
MAPT P10636 1/20 0.40
NAMPT P43490 1/20 0.40
TLR7 Q9NYK1 1/20 0.40
ENPP2 Q13822 3/20 0.39
ATXN2 Q99700 3/20 0.39
TGFBR1 P36897 1/20 0.39
MC4R P32245 1/20 0.39
USP30 Q70CQ3 1/20 0.38
EPHX2 P34913 1/20 0.38
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19409666 0.85 IDO1 (0.43) IDO1GPR119RORCTACR1DPP4
SCHEMBL21723050 0.85 MGLL (0.51) GPR119RORCTACR1DPP4MAPT
SCHEMBL19833730 0.83 CHRNA7 (0.53) GPR119RORCTACR1MAPTNAMPT
SCHEMBL22462905 0.81 RORC (0.43) GPR119RORCTACR1DPP4MAPT
SCHEMBL29962387 0.81 IDO1 (0.42) IDO1GPR119RORCTACR1DPP4
SCHEMBL25327924 0.80 SCN9A (0.48) GPR119RORCTACR1DPP4MAPT
SCHEMBL25259349 0.80 TACR1 (0.47) GPR119RORCTACR1DPP4MAPT
SCHEMBL28540034 0.78 DPP4 (0.51) GPR119RORCDPP4MAPTTLR7
SCHEMBL25325368 0.78 SLC6A4 (0.47) RORCTACR1DPP4MAPTENPP2
SCHEMBL25325509 0.78 SLC6A4 (0.47) RORCTACR1DPP4TGFBR1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-01-22 US disclosed
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2025-04-22 US disclosed
EP-4474017-A2 NEW HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2024-12-11 EP disclosed
EP-3837263-B1 NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN LA ROCHE (CH) 2024-07-03 EP disclosed
US-20240150373-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2024-05-09 US disclosed
US-11802133-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors HOFFMANN-LA ROCHE INC. (US) 2023-10-31 US disclosed
US-20230050901-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2023-02-16 US disclosed
US-20210277020-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2021-09-09 US disclosed
US-20200308190-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2020-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210277020-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS MGLL, PNLIP, LPL IDO1 3585/4885GPR119 144/4885RORC 4593/4885
US-20260022130-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LIPA, LPL IDO1 3544/4885GPR119 192/4885RORC 3369/4885
US-12281124-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL IDO1 3378/4885GPR119 53/4885RORC 4252/4885
US-20240150373-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LPL, MGLL IDO1 3378/4885GPR119 53/4885RORC 4252/4885
US-20200308190-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, MGLL, LPL IDO1 3714/4885GPR119 63/4885RORC 4211/4885
US-11802133-B2 Heterocyclic compounds as monoacylglycerol lipase inhibitors LIPC, LPL, MGLL IDO1 3378/4885GPR119 53/4885RORC 4252/4885
US-20230050901-A1 HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS LIPC, LPL, MGLL IDO1 3378/4885GPR119 53/4885RORC 4252/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.