Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.58 |
| ▸ | HPGDS | O60760 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247532 | 0.86 | CA2 (0.58) | MMP12CA1CA2MMP2HDAC2 | |
| SCHEMBL2246054 | 0.85 | MMP12 (0.76) | MMP12HPGDSCA1CA12CA9 | |
| SCHEMBL2245321 | 0.85 | MMP12 (0.76) | MMP12HPGDSCA1CA12CA9 | |
| SCHEMBL2245742 | 0.82 | PTPN2 (0.56) | MMP12HPGDSPTPN1 | |
| SCHEMBL3579193 | 0.82 | ADAMTS5 (0.50) | MMP12ADAMTS5ADAMTS4MMP2MMP8 | |
| SCHEMBL28108803 | 0.80 | HPGDS (0.69) | MMP12HPGDSCA1CA12CA9 | |
| SCHEMBL10518630 | 0.80 | HPGDS (0.69) | MMP12HPGDSCA1CA12CA9 | |
| SCHEMBL2247335 | 0.80 | C3AR1 (0.46) | MMP12HPGDSPTPN1MMP2MMP8 | |
| SCHEMBL2245606 | 0.80 | MMP12 (0.65) | MMP12HPGDSCA1CA12CA9 | |
| SCHEMBL2248624 | 0.78 | MMP12 (0.64) | MMP12HPGDSCA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |