Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21395273 | 0.84 | LMNA (0.47) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL21384024 | 0.81 | MARS1 (0.43) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL21383951 | 0.79 | PTGER4 (0.43) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL21394893 | 0.74 | LMNA (0.39) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL21383972 | 0.70 | PTGS2 (0.44) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL12877231 | 0.70 | TSHR (0.37) | ALDH1A1SMN1; SMN2KDM4EMAPTKMT2A | |
| SCHEMBL8149332 | 0.70 | MAPT (0.36) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29359042 | 0.69 | SMN1; SMN2 (0.45) | LMNASAE1UBA2USP2THRB | |
| SCHEMBL29353756 | 0.68 | SMN1; SMN2 (0.41) | LMNASAE1UBA2AURKARPS6KB1 | |
| SCHEMBL29358443 | 0.68 | RAB9A (0.46) | LMNASAE1UBA2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |