Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | HPGDS | O60760 | 4/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245321 | 0.90 | MMP12 (0.76) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL2246054 | 0.90 | MMP12 (0.76) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL2248588 | 0.86 | MMP12 (0.57) | MMP12PTPN1HPGDSADAMTS4CTSL | |
| SCHEMBL2249558 | 0.86 | CA2 (0.58) | MMP12PTPN1HPGDSUTS2RCA1 | |
| SCHEMBL2248730 | 0.84 | HPGDS (0.83) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL3584960 | 0.83 | CTSL (0.55) | MMP12ADAMTS4ADAMTS5CTSLCTSB | |
| SCHEMBL10518630 | 0.83 | HPGDS (0.69) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL28108803 | 0.83 | HPGDS (0.69) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL2252391 | 0.82 | MMP12 (0.66) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 | |
| SCHEMBL2245606 | 0.82 | MMP12 (0.65) | MMP12PTPN1HPGDSADAMTS4ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |