SCHEMBL22490896

SCHEMBL22490896

Cc1c(C(=O)CO[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2O)cc(Cl)c(O)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC28A3 Q9HAS3 2/20 0.34
SLC5A1 P13866 2/20 0.33
SLC5A2 P31639 2/20 0.33
HK1 P19367 1/20 0.33
HK2 P52789 1/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
ALDH1A1 P00352 2/20 0.33
CYP3A4 P08684 2/20 0.33
MAPT P10636 2/20 0.33
MAPK1 P28482 2/20 0.33
RECQL P46063 2/20 0.33
KMT2A Q03164 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
MMP14 P50281 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HPGD P15428 1/20 0.32
PTPN1 P18031 1/20 0.32
APEX1 P27695 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL22490928 0.77 ADORA1 (0.34) SLC5A1SLC5A2
SCHEMBL22490853 0.76 NPC1 (0.39) SLC28A3SLC5A1SLC5A2ALDH1A1POLB
SCHEMBL23488249 0.76 LGALS3 (0.47)
SCHEMBL22490897 0.74 SLC5A2 (0.31) SLC5A1SLC5A2
SCHEMBL22490920 0.74 POLB (0.41) SLC28A3SLC5A2POLB
SCHEMBL22490910 0.73 LGALS8 (0.37) SLC5A1SLC5A2KDM4EALDH1A1
SCHEMBL23488591 0.72 CA2 (0.52) MEN1KMT2A
SCHEMBL4286474 0.64 ACHE (0.38) SLC28A3SLC5A1SLC5A2PTPN1POLB
SCHEMBL7758835 0.63 SLC2A1 (0.44) MAPK1
SCHEMBL18037637 0.63 SLC2A1 (0.44) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 SLC28A3 191/4885SLC5A1 9/4885SLC5A2 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.