SCHEMBL22490920

SCHEMBL22490920

Cc1c(C(=O)NCO[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc(Cl)c(O)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.41
APP P05067 1/20 0.40
SLC28A3 Q9HAS3 1/20 0.40
SLC5A2 P31639 1/20 0.39
ACHE P22303 2/20 0.39
BACE1 P56817 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23488591 0.81 CA2 (0.52)
SCHEMBL23488249 0.75 LGALS3 (0.47)
SCHEMBL22490896 0.74 SLC28A3 (0.34) POLBSLC28A3SLC5A2
SCHEMBL22490897 0.69 SLC5A2 (0.31) SLC5A2
SCHEMBL11986813 0.66 SLC28A3 (0.50) POLBAPPSLC28A3SLC5A2
SCHEMBL8652659 0.64 APP (0.55) POLBAPPSLC28A3SLC5A2
SCHEMBL4378546 0.63 SLC28A3 (0.56) POLBAPPSLC28A3ACHE
SCHEMBL18037641 0.63 IGF2R (0.47) ACHEBACE1
SCHEMBL18037636 0.63 IGF2R (0.47) ACHEBACE1
SCHEMBL3268722 0.62 LGALS8 (0.51) SLC28A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 POLB 4867/4885APP 3466/4885SLC28A3 191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.