SCHEMBL22492152

SCHEMBL22492152

Cc1cccc(C(=O)NC(C)CC#N)c1N

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
CTSV O60911 2/20 0.39
CTSL P07711 2/20 0.39
CTSS P25774 2/20 0.39
CTSK P43235 1/20 0.39
ALDH1A1 P00352 4/20 0.37
KDM4E B2RXH2 3/20 0.37
POLB P06746 3/20 0.36
CHRM2 P08172 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C19 P33261 1/20 0.36
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HSD17B10 Q99714 1/20 0.35
ATM Q13315 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27744255 0.82 ALDH1A1 (0.39) CTSVCTSLCTSSCTSKALDH1A1
SCHEMBL22492164 0.80 HPGD (0.56) MEN1KMT2AALDH1A1POLBCYP1A2
SCHEMBL3194752 0.79 ALOX5 (0.49) ALDH1A1KDM4ECHRM2CYP1A2CYP2C19
SCHEMBL22492157 0.79 ALDH1A1 (0.39) MEN1KMT2ACTSVCTSLCTSS
SCHEMBL2062239 0.79 HPGD (0.46) MEN1KMT2ACTSVCTSLCTSS
SCHEMBL21612254 0.75 ALDH1A1 (0.38) MEN1KMT2AALDH1A1KDM4ECHRM2
SCHEMBL10101480 0.75 CNR1 (0.41) MEN1KMT2AALDH1A1KDM4ECHRM2
SCHEMBL22492155 0.75 KMT2A (0.34) MEN1KMT2ACTSVCTSLCTSS
SCHEMBL5584122 0.74 ALDH1A1 (0.43) KMT2AALDH1A1KDM4EPOLBCHRM2
SCHEMBL31301322 0.71 MEN1 (0.51) MEN1KMT2AALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3719011-B1 PYRAZOLE AMIDE COMPOUND HAVING PESTICIDAL ACTIVITY AND USE THEREOF JIANGSU FLAG CHEM IND CO LTD (CN) 2023-03-29 EP disclosed
CN-109988149-B Pyrazole amide compound with insecticidal activity and application thereof 江苏中旗科技股份有限公司 2022-04-12 CN disclosed
US-20200329707-A1 PYRAZOLAMIDE COMPOUND HAVING INSECTICIDAL ACTIVITY AND USE THEREOF JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD. (CN) 2020-10-22 US disclosed
EP-3719011-A1 PYRAZOLE AMIDE COMPOUND HAVING PESTICIDAL ACTIVITY AND USE THEREOF Jiangsu Flag Chemical Industry Co., Ltd. (CN) 2020-10-07 EP disclosed
CN-109988149-A A kind of pyrazol acid amide compounds and its application with insecticidal activity 江苏中旗科技股份有限公司 2019-07-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200329707-A1 PYRAZOLAMIDE COMPOUND HAVING INSECTICIDAL ACTIVITY AND USE THEREOF KCNH1, CA3, KCNH3 MEN1 2742/4885KMT2A 2177/4885CTSV 634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.