Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.55 |
| ▸ | MPO | P05164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.53 |
| ▸ | YAP1 | P46937 | 1/20 | 0.53 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triflocin SCHEMBL3088829 | 0.88 | MPO (0.65) | MAPK8RXFP1MPOMEN1KMT2A | |
| SCHEMBL19657901 | 0.85 | RXFP1 (0.70) | MAPK8RXFP1MPOAKR1C3AKR1C2 | |
| SCHEMBL22492796 | 0.84 | PTGS1 (0.53) | MAPK8MEN1KMT2AAURKACSNK2A1 | |
| SCHEMBL23547199 | 0.84 | MAPK13 (0.50) | MAPK8MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL6257310 | 0.81 | SORT1 (0.54) | RXFP1MPOMEN1KMT2ATEAD4 | |
| SCHEMBL11393764 | 0.79 | CYP11B2 (0.49) | RXFP1MPOMEN1KMT2ATSHR | |
| SCHEMBL23547202 | 0.79 | CSNK2A1 (0.45) | MAPK8MEN1KMT2ATSHRAURKA | |
| SCHEMBL23547203 | 0.78 | POLB (0.55) | MEN1KMT2AAKR1C3AKR1C2MAPT | |
| SCHEMBL22492749 | 0.78 | PTGS1 (0.54) | MAPK8KMT2ACSNK2A1LMNACYP3A4 | |
| SCHEMBL22492824 | 0.78 | LMNA (0.78) | RXFP1MEN1KMT2ATEAD4YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188763-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | UNIV CALIFORNIA (US) | 2021-06-24 | — | — | US | disclosed |
| US-20210188763-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | UNIV CALIFORNIA (US) | 2021-06-24 | — | — | US | disclosed |
| EP-3717450-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | The Regents of the University of California (US) | 2020-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188763-A1 | COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION | HGF, CXCL12, CCL11 | MAPK8 3072/4885RXFP1 2467/4885MPO 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.