SCHEMBL22497968

SCHEMBL22497968

C[C@@H](O)c1nccnc1Cl

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.31
NPC1 O15118 2/20 0.31
GAA P10253 2/20 0.31
PKM P14618 1/20 0.31
RAB9A P51151 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30762127 1.00 DYRK1A (0.31) DYRK1ANPC1GAAPKMRAB9A
SCHEMBL6937377 1.00 DYRK1A (0.31) DYRK1ANPC1GAAPKMRAB9A
SCHEMBL2742982 0.80 CCNB2 (0.30)
SCHEMBL12165147 0.80 LMNA (0.31)
SCHEMBL29434479 0.76 ADRB2 (0.34) NPC1GAARAB9A
SCHEMBL22497935 0.76 ADRB2 (0.34) NPC1GAARAB9A
SCHEMBL6937966 0.76 ADRB2 (0.34) NPC1GAARAB9A
SCHEMBL12335161 0.76
Hydrochloric Acid SCHEMBL21823105 0.74 NPC1 (0.33) NPC1GAAPKMRAB9AL3MBTL1
Hydrochloric Acid SCHEMBL22498583 0.74 NPC1 (0.33) NPC1GAAPKMRAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583851-B2 Heteroaryl-substituted pyrazine derivatives as pesticides ELANCO ANIMAL HEALTH GMBH (DE) 2026-03-24 US disclosed
US-12527325-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2026-01-20 US disclosed
EP-3947358-B1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-06-18 EP disclosed
CN-113661165-B Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2025-05-23 CN disclosed
US-12281095-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 US disclosed
CN-113631549-B Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2025-01-17 CN disclosed
US-20230023326-A1 HETEROARYL-SUBSTITUTED PYRAZINE DERIVATIVES AS PESTICIDES ELANCO ANIMAL HEALTH GMBH (DE) 2023-01-26 US disclosed
US-20220289715-A1 PESTICIDALLY ACTIVE PYRAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-09-15 US disclosed
EP-4041720-A1 HETEROARYL-SUBSTITUTED PYRAZINE DERIVATIVES AS PESTICIDES Bayer Animal Health GmbH (DE) 2022-08-17 EP disclosed
CN-114761393-A Heteroaryl substituted pyrazine derivatives as pesticides 拜耳动物保健有限责任公司 2022-07-15 CN disclosed
CN-113661165-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-16 CN disclosed
CN-113631549-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-09 CN disclosed
WO-2021037614-A1 PESTICIDALLY ACTIVE PYRAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-03-04 WO disclosed
WO-2021037614-A1 PESTICIDALLY ACTIVE PYRAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-03-04 WO disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020208036-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-15 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed
WO-2020201398-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed
WO-2020201398-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583851-B2 Heteroaryl-substituted pyrazine derivatives as pesticides CBR3, CYCS, CWC15 DYRK1A 4474/4885NPC1 633/4885GAA 4709/4885
US-12527325-B2 Pesticidally active diazine-amide compounds DDT, CHRM1, C3AR1 DYRK1A 2086/4885NPC1 1028/4885GAA 4225/4885
US-20220289715-A1 PESTICIDALLY ACTIVE PYRAZINE-AMIDE COMPOUNDS ACHE, DDT, NAT1 DYRK1A 2177/4885NPC1 3343/4885GAA 4057/4885
US-20230023326-A1 HETEROARYL-SUBSTITUTED PYRAZINE DERIVATIVES AS PESTICIDES DDT, PRXL2A, CAT DYRK1A 1914/4885NPC1 4458/4885GAA 4409/4885
US-12281095-B2 Pesticidally active diazine-amide compounds DDT, ACHE, NIT2 DYRK1A 822/4885NPC1 2626/4885GAA 2770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.