Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455469 | 0.85 | ACHE (0.68) | SMN1; SMN2KDM4ELMNAACHEL3MBTL3 | |
| SCHEMBL25658379 | 0.84 | HSD11B1 (0.57) | ALDH1A1SMN1; SMN2POLBACHEL3MBTL3 | |
| SCHEMBL12384398 | 0.84 | GAA (0.60) | MAPTALDH1A1MAPK1GAAPOLB | |
| SCHEMBL27022587 | 0.83 | L3MBTL3 (0.51) | ALDH1A1SMN1; SMN2POLBACHEL3MBTL3 | |
| SCHEMBL13744553 | 0.81 | ACHE (0.72) | ALDH1A1SMN1; SMN2RECQLGAAKDM4E | |
| SCHEMBL12404030 | 0.80 | EPHX2 (0.52) | ALDH1A1SMN1; SMN2MAPK1RECQLGAA | |
| SCHEMBL22119220 | 0.80 | KDM4E (0.59) | SMN1; SMN2RECQLGAAKDM4EPOLB | |
| SCHEMBL14393583 | 0.78 | RECQL (0.51) | ALDH1A1SMN1; SMN2MAPK1RECQLGAA | |
| SCHEMBL4703329 | 0.78 | KDM4E (0.61) | SMN1; SMN2RECQLGAAKDM4EPOLB | |
| SCHEMBL4703332 | 0.78 | KDM4E (0.57) | SMN1; SMN2RECQLGAAKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-15 | — | — | US | disclosed |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | GRUENENTHAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, OPRL1 | MAPT 3594/4885ALDH1A1 250/4885SMN1; SMN2 816/4885 |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | MAPT 3594/4885ALDH1A1 250/4885SMN1; SMN2 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.