Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.41 |
| ▸ | NNMT | P40261 | 15/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002025 | 0.81 | AHCY (0.52) | PRMT5WDR77NNMT | |
| SCHEMBL19991765 | 0.81 | NNMT (0.41) | PRMT5WDR77NNMT | |
| SCHEMBL9109736 | 0.81 | AHCY (0.52) | PRMT5WDR77NNMT | |
| SCHEMBL18572585 | 0.81 | AHCY (0.52) | PRMT5WDR77NNMT | |
| SCHEMBL18571708 | 0.80 | PRMT5 (0.51) | PRMT5WDR77NNMT | |
| SCHEMBL20049521 | 0.80 | PIP4K2A (0.39) | PRMT5WDR77NNMT | |
| SCHEMBL18572584 | 0.80 | PIP4K2A (0.39) | PRMT5WDR77NNMT | |
| SCHEMBL9469927 | 0.80 | NNMT (0.42) | PRMT5WDR77NNMT | |
| SCHEMBL1441891 | 0.79 | PIP4K2A (0.42) | PRMT5WDR77NNMT | |
| SCHEMBL9950030 | 0.79 | PIP4K2A (0.42) | PRMT5WDR77NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3585904-B1 | USE OF BIOMARKERS IN IDENTIFYING CANCER PATIENTS THAT WILL BE RESPONSIVE TO TREATMENT WITH A PRMT5 INHIBITOR | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-29 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |