Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL30662801 | 1.00 | ACHE (0.47) | ACHEBACE1TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL5336280 | 1.00 | ACHE (0.47) | ACHEBACE1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL28488128 | 0.86 | HCAR2 (0.40) | ACHEBACE1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL28046211 | 0.86 | ACHE (0.58) | ACHEBACE1TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL10835017 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Maleic Acid SCHEMBL28887158 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Maleic Acid SCHEMBL29780364 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Fumaric Acid SCHEMBL28962418 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Fumaric Acid SCHEMBL28760858 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Bicarbonate SCHEMBL10590002 | 0.84 | HDAC1 (0.52) | TSHRCHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725518-B1 | LAMINATED STEEL HAVING EXTREMELY LOW INTERFACE BUBBLE RATE AND METHOD FOR MANUFACTURING SAME | BAOSHAN IRON & STEEL (CN) | 2024-10-09 | — | — | EP | disclosed |
| CN-114395116-A | Polyester hydrazide, rubber composition, tire and preparation method and application thereof | 江苏麒祥高新材料有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-111848394-A | Synthesis method and application of maleic acid dihydric alcohol mono-tertiary butyl ether diester | 深圳飞扬兴业科技有限公司 | 2020-10-30 | — | — | CN | disclosed |
| EP-3725518-A1 | LAMINATED STEEL HAVING EXTREMELY LOW INTERFACE BUBBLE RATE AND METHOD FOR MANUFACTURING SAME | BAOSHAN IRON & STEEL CO., LTD. (CN) | 2020-10-21 | — | — | EP | disclosed |
| CN-105367771-B | A kind of lactyl aliphatic random copolymer and preparation method thereof | 中国科学院长春应用化学研究所 | 2018-02-13 | — | — | CN | disclosed |
| CN-105542134-B | A kind of lactyl aliphatic aromatic random copolymer | 中国科学院长春应用化学研究所 | 2017-11-28 | — | — | CN | disclosed |
| CN-105622911-B | A kind of unsaturated aliphatic aromatic series polylactic-acid block copolymer | 中国科学院长春应用化学研究所 | 2017-11-28 | — | — | CN | disclosed |
| CN-105368019-B | Polylactic acid stereo complex | 中国科学院长春应用化学研究所 | 2017-04-19 | — | — | CN | disclosed |