Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.44 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL22551491 | 1.00 | ACHE (0.47) | ACHEBACE1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL30662801 | 1.00 | ACHE (0.47) | ACHEBACE1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL28488128 | 0.86 | HCAR2 (0.40) | ACHEBACE1TSHRTP53EGLN1 | |
| Maleic Acid SCHEMBL28046211 | 0.86 | ACHE (0.58) | ACHEBACE1TSHRTP53EGLN1 | |
| Fumaric Acid SCHEMBL10835017 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Maleic Acid SCHEMBL28887158 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Maleic Acid SCHEMBL29780364 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Fumaric Acid SCHEMBL28962418 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Fumaric Acid SCHEMBL28760858 | 0.84 | GPR84 (0.52) | ACHEBACE1HCAR2 | |
| Bicarbonate SCHEMBL10590002 | 0.84 | HDAC1 (0.52) | TSHRCHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114395116-B | Polyester hydrazide, rubber composition, tire, preparation method and application thereof | 江苏麒祥高新材料有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-113200853-A | Process method for preparing butanediol succinate | 宁波窦氏化学科技有限公司 | 2021-08-03 | — | — | CN | disclosed |
| CN-103910821-B | A kind of high pressure resistant water penetration porous material and preparation method thereof | 中科院广州化学有限公司南雄材料生产基地 | 2016-08-17 | — | — | CN | disclosed |
| US-7265166-B2 | Aqueous polymer composition | ROHM AND HAAS COMPANY (US) | 2007-09-04 | — | — | US | disclosed |
| CN-1312212-C | Aqueous polymer blend composition | ROHM & HAAS (US) | 2007-04-25 | — | — | CN | disclosed |
| US-6930141-B2 | Antisoilants; wear resistance; acrylated polymer | ROHM AND HAAS COMPANY (US) | 2005-08-16 | — | — | US | disclosed |
| US-20050009954-A1 | Aqueous polymer composition | ROHM AND HAAS COMPANY | 2005-01-13 | — | — | US | disclosed |
| EP-1496091-A1 | Aqueous polymer composition | ROHM AND HAAS COMPANY (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20040010071-A1 | Aqueous polymer blend composition | ROHM AND HAAS COMPANY | 2004-01-15 | — | — | US | disclosed |
| CN-1450114-A | Aqueous polymer blend composition | ROHM & HAAS (US) | 2003-10-22 | — | — | CN | disclosed |
| EP-1352924-A1 | Aqueous polymer blend composition | ROHM AND HAAS COMPANY (US) | 2003-10-15 | — | — | EP | disclosed |
| US-4108671-A | Dye-based inks with improved vehicles | RICHLIN MILTON | 1978-08-22 | — | — | US | disclosed |