Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A known ✓ | P04350 | 1/20 | 0.70 |
| ▸ | TUBB known ✓ | P07437 | 1/20 | 0.70 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 1/20 | 0.70 |
| ▸ | TUBA1B known ✓ | P68363 | 1/20 | 0.70 |
| ▸ | TUBA4A known ✓ | P68366 | 1/20 | 0.70 |
| ▸ | TUBB4B known ✓ | P68371 | 1/20 | 0.70 |
| ▸ | TUBB3 known ✓ | Q13509 | 1/20 | 0.70 |
| ▸ | TUBB2A known ✓ | Q13885 | 1/20 | 0.70 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 1/20 | 0.70 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 1/20 | 0.70 |
| ▸ | TUBA1A known ✓ | Q71U36 | 1/20 | 0.70 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 1/20 | 0.70 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 1/20 | 0.70 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 1/20 | 0.70 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29902897 | 0.95 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552106 | 0.95 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29903024 | 0.95 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552082 | 0.89 | TUBB4A (0.89) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29902959 | 0.89 | TUBB4A (0.89) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552141 | 0.85 | ALDH1A1 (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29902925 | 0.85 | ALDH1A1 (0.67) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552142 | 0.84 | TUBB4A (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552130 | 0.83 | TUBB4A (0.79) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22552107 | 0.83 | TUBB4A (0.79) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12109207-B2 | Methods of using 4(1H)-quinolone derivatives | ACADEMIA SINICA (TW) | 2024-10-08 | — | — | US | disclosed |
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | ACADEMIA SINICA (TW) | 2023-07-27 | — | — | US | disclosed |
| US-11638705-B2 | 4(1H)-quinolone derivatives and uses thereof | ACADEMIA SINICA (TW) | 2023-05-02 | — | — | US | disclosed |
| CN-111825611-B | 4(1H) -quinovone derivatives and uses thereof | 刘扶东 | 2022-09-09 | — | — | CN | disclosed |
| CN-111825611-A | 4(1H) -quinovone derivatives and uses thereof | 中央研究院 | 2020-10-27 | — | — | CN | disclosed |
| US-20200330449-A1 | 4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF | ACADEMIA SINICA (TW) | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11638705-B2 | 4(1H)-quinolone derivatives and uses thereof | TUBB1, TUBB3, TUBB | TUBB4A 5/4885TUBB 3/4885TUBA3C 19/4885 |
| US-12109207-B2 | Methods of using 4(1H)-quinolone derivatives | TUBB1, TUBB3, TUBB | TUBB4A 6/4885TUBB 3/4885TUBA3C 20/4885 |
| US-20200330449-A1 | 4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF | TUBB1, TUBB3, TUBA1C | TUBB4A 5/4885TUBB 4/4885TUBA3C 18/4885 |
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | TUBB1, TUBB3, TUBB | TUBB4A 6/4885TUBB 3/4885TUBA3C 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.