SCHEMBL22562492

SCHEMBL22562492

FC(F)(F)c1cc(-n2c3cc(-c4ccccc4)ccc3c3ccc(-c4ccccc4)cc32)c(-c2cccc(-c3ccccc3)n2)cc1-n1c2cc(-c3ccccc3)ccc2c2ccc(-c3ccccc3)cc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 2/20 0.40
MEN1 O00255 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
PTGES O14684 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ACHE P22303 4/20 0.33
LDHA P00338 1/20 0.33
PIM1 P11309 1/20 0.32
CDK4 P11802 1/20 0.32
CCND3 P30281 1/20 0.32
GSK3B P49841 1/20 0.32
C1S P09871 1/20 0.32
PDK2 Q15119 1/20 0.32
CYP11B1 P15538 1/20 0.32
NT5E P21589 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
ADORA2A P29274 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562627 0.92 KIF11 (0.40) CYP11B2PDK2HSD11B1
SCHEMBL22562290 0.92 CYP11B2 (0.41) CYP11B2MEN1RAB9AKMT2APTGES
SCHEMBL22562427 0.92 CYP11B2 (0.36) CYP11B2MEN1RAB9AKMT2ALDHA
SCHEMBL22562496 0.91 CYP11B2 (0.40) CYP11B2MEN1RAB9AKMT2APTGES
SCHEMBL22562491 0.90 CYP11B2 (0.38) CYP11B2MEN1RAB9AKMT2AACHE
SCHEMBL22562498 0.90 MAT2A (0.39) CYP11B2MEN1RAB9AKMT2ACYP3A4
SCHEMBL22562422 0.89 CYP11B2 (0.34) CYP11B2MEN1RAB9AKMT2APIM1
SCHEMBL22562327 0.89 ALDH1A3 (0.36) CYP11B2PDK2
SCHEMBL22157593 0.89 CYP11B2 (0.38) CYP11B2MEN1RAB9AKMT2APTGES
SCHEMBL22156714 0.87 CYP11B2 (0.42) CYP11B2MEN1RAB9AKMT2AACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed