Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21185287 | 0.84 | MAPT (0.55) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL22566563 | 0.82 | MEN1 (0.61) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL4251968 | 0.76 | RXFP1 (0.94) | TSHRMEN1KMT2APOLBNPC1 | |
| SCHEMBL30862297 | 0.76 | RXFP1 (0.94) | TSHRMEN1KMT2APOLBNPC1 | |
| SCHEMBL21348647 | 0.75 | SMN1; SMN2 (0.73) | TSHRMEN1KMT2APOLBNPC1 | |
| SCHEMBL22566547 | 0.75 | ALDH1A1 (0.55) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL5309636 | 0.74 | SIRT1 (0.78) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL16384042 | 0.73 | LCLAT1 (1.00) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL22566644 | 0.73 | TUBB4A (0.59) | HSD17B10TSHRALOX15MEN1KMT2A | |
| SCHEMBL3025464 | 0.73 | RXFP1 (0.76) | TSHRMEN1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-08-10 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-11639345-B2 | Methionine metabolic pathway inhibitors | MIGAL—GALILEE RESEARCH INSTITUTE LTD. (IL) | 2023-05-02 | — | — | US | disclosed |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | MIGAL - GALILEE RESEARCH INSTITUTE LTD. (IL) | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639345-B2 | Methionine metabolic pathway inhibitors | GSS, MTR, CTH | HSD17B10 681/4885TSHR 1942/4885ALOX15 2274/4885 |
| US-20200331872-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | HSD17B10 681/4885TSHR 1942/4885ALOX15 2274/4885 |
| US-20230250086-A1 | METHIONINE METABOLIC PATHWAY INHIBITORS | GSS, MTR, CTH | HSD17B10 681/4885TSHR 1942/4885ALOX15 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.