Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12361559 | 1.00 | MAPT (0.38) | MAPTMAPK1KDM4EL3MBTL1MEN1 | |
| SCHEMBL29264501 | 0.79 | MEN1 (0.45) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL12361556 | 0.73 | ADORA3 (0.39) | MAPTMAPK1KDM4EL3MBTL1MEN1 | |
| SCHEMBL2258432 | 0.73 | ADORA3 (0.39) | MAPTMAPK1KDM4EL3MBTL1MEN1 | |
| SCHEMBL25059407 | 0.71 | ADORA3 (0.35) | MAPTMAPK1KDM4EL3MBTL1MEN1 | |
| SCHEMBL18977996 | 0.69 | NOS2 (0.43) | MEN1KMT2AHSD17B10SMN1; SMN2P2RX7 | |
| SCHEMBL26703813 | 0.68 | MEN1 (0.44) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL28512297 | 0.67 | MEN1 (0.44) | MAPTMAPK1KDM4EMEN1KMT2A | |
| SCHEMBL12361561 | 0.67 | ALDH1A1 (0.37) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL25935172 | 0.67 | ADORA3 (0.33) | MAPTL3MBTL1GAAIDO1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994169-B2 | By condensation with a 1,2 carbonyl compound such as glyxoal to form ring and then reduction to form the tetrahydropyrido[3,4-b]pyrazine; acylation catalyst for esterification of ethynylcyclohexanol with acetic anhydride | BAYER MATERIALSCIENCE AG (DE) | 2011-08-09 | — | — | US | disclosed |
| EP-2094710-B1 | 3,4 DIAMINOPYRIDINE DERIVATIVES | BAYER MATERIALSCIENCE AG (DE) | 2010-05-26 | — | — | EP | disclosed |
| EP-2094710-A1 | 3,4 DIAMINOPYRIDINE DERIVATIVES | Bayer MaterialScience AG (DE) | 2009-09-02 | — | — | EP | disclosed |
| US-20080176747-A1 | 3,4-diaminopyridine derivatives | BAYER MATERIALSCIENCE AG (DE) | 2008-07-24 | — | — | US | disclosed |
| WO-2008067965-A1 | 3,4 DIAMINOPYRIDINE DERIVATIVES | BAYER MATERIALSCIENCE AG (DE) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176747-A1 | 3,4-diaminopyridine derivatives | DPYD, QDPR, DDC | MAPT 3025/4885MAPK1 1443/4885KDM4E 1152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.