SCHEMBL2263957

SCHEMBL2263957

O=Cc1c[nH]c2ccncc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 2/20 0.62
CDK9 P50750 2/20 0.62
HASPIN Q8TF76 2/20 0.62
CYP2A6 P11509 3/20 0.56
IMPDH2 P12268 1/20 0.56
KMT2A Q03164 1/20 0.50
HTR6 P50406 2/20 0.47
ALDH1A1 P00352 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C19 P33261 1/20 0.46
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
PLG P00747 1/20 0.41
PLAU P00749 1/20 0.41
GABRP O00591 1/20 0.40
GABRD O14764 1/20 0.40
GABRA1 P14867 1/20 0.40
GABRB1 P18505 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2268299 0.85 CCNT1 (0.62) CCNT1CDK9HASPINCYP2A6IMPDH2
SCHEMBL29664462 0.85 CCNT1 (0.62) CCNT1CDK9HASPINCYP2A6IMPDH2
Hydrochloric Acid SCHEMBL3831446 0.84 CCNT1 (0.60) CCNT1CDK9HASPINCYP2A6IMPDH2
SCHEMBL28321030 0.81 HTR6 (0.47) CCNT1CDK9HASPINIMPDH2HTR6
SCHEMBL29954562 0.75 CCNT1 (0.58) CCNT1CDK9HASPINCYP2A6IMPDH2
SCHEMBL3459147 0.74 CCNT1 (0.56) CCNT1CDK9HASPINCYP2A6IMPDH2
3-Formylindole SCHEMBL29082887 0.74 CYP2A6 (0.77) CCNT1CDK9HASPINCYP2A6IMPDH2
SCHEMBL23600366 0.74 CGAS (0.51) CCNT1CDK9HASPINKMT2AHTR6
SCHEMBL6755476 0.74 APP (0.63) CCNT1CDK9HASPINKMT2AHTR6
SCHEMBL23582847 0.73 PIM1 (0.38) CCNT1CDK9HASPINKMT2AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090330-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2026-04-30 WO disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3440097-B1 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80/PD-L1 PROTEIN/PROTEIN INTERACTIONS BRISTOL MYERS SQUIBB CO (US) 2024-10-23 EP disclosed
US-12012411-B2 Viral replication inhibitors KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2024-06-18 US disclosed
US-11958837-B2 Quinazolinones as PARP14 inhibitors RIBON THERAPEUTICS, INC. (US) 2024-04-16 US disclosed
CN-110526854-B Alpha, beta-unsaturated ketone derivative, preparation method and application thereof as medicine 宁夏医科大学 2023-12-15 CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
WO-2023154314-A1 SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-08-17 WO disclosed
EP-4212515-A1 QUINAZOLINONES AS PARP14 INHIBITORS Ribon Therapeutics Inc. (US) 2023-07-19 EP disclosed
US-20230145249-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-05-11 US disclosed
WO-2017176608-A1 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80/PD-L1 PROTEIN/PROTEIN INTERACTIONS BRISTOL-MYERS SQUIBB COMPANY (US) 2017-10-12 WO disclosed
US-20170283463-A1 IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY 2017-10-05 US disclosed
US-20170283463-A1 IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY 2017-10-05 US disclosed
US-20170283463-A1 IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY 2017-10-05 US disclosed
CN-104024223-A Inhibitors of viral replication UNIV LEUVEN KATH 2014-09-03 CN disclosed
US-20140213586-A1 VIRAL REPLICATION INHIBITORS KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2014-07-31 US disclosed
US-8003649-B2 Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 ASTRAZENECA AB (SE) 2011-08-23 US disclosed
EP-2235010-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS AstraZeneca AB (SE) 2010-10-06 EP disclosed
US-20100016279-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 ASTRAZENECA AB (SE) 2010-01-21 US disclosed
WO-2009081197-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS ASTRAZENECA AB (SE) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11958837-B2 Quinazolinones as PARP14 inhibitors PARP14, PARP15, PARP11 CCNT1 1828/4885CDK9 330/4885HASPIN 815/4885
US-20170283463-A1 IMMUNOMODULATORS CD274, PDCD1, PDCD1LG2 CCNT1 2034/4885CDK9 2002/4885HASPIN 398/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH CCNT1 4702/4885CDK9 3876/4885HASPIN 4644/4885
US-20230145249-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP CCNT1 3710/4885CDK9 2494/4885HASPIN 4671/4885
US-20140213586-A1 VIRAL REPLICATION INHIBITORS EIF2AK2, MAVS, ZC3HAV1 CCNT1 781/4885CDK9 346/4885HASPIN 1643/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP CCNT1 3710/4885CDK9 2494/4885HASPIN 4671/4885
US-20100016279-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 AR, NR5A1, CYP17A1 CCNT1 1437/4885CDK9 2178/4885HASPIN 3025/4885
US-12012411-B2 Viral replication inhibitors EIF2AK2, MAVS, ZC3HAV1 CCNT1 781/4885CDK9 346/4885HASPIN 1643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.