Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSC | P53634 | 3/20 | 0.54 |
| ▸ | RXRA | P19793 | 12/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22642979 | 0.80 | NOTUM (0.60) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643118 | 0.79 | P2RX7 (0.60) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643391 | 0.75 | KCNH2 (0.58) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643248 | 0.74 | CTSK (0.55) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643453 | 0.74 | KCNH2 (0.57) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643285 | 0.74 | CTSK (0.49) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL22643110 | 0.73 | CA9 (0.51) | CTSKCTSCRXRAGRIN1GRIN2B | |
| SCHEMBL16064307 | 0.72 | CTSC (1.00) | CTSKCTSC | |
| SCHEMBL19220682 | 0.70 | RXRA (0.69) | RXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL30031099 | 0.70 | NOTUM (0.50) | RXRAGRIN1GRIN2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |