Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MUSK | O15146 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FER | P16591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650536 | 0.90 | JAK2 (0.34) | SYKJAK2BRD4CDK9CDK1 | |
| SCHEMBL22650578 | 0.85 | IKBKB (0.35) | JAK2BRD4CDK9CDK1CCNB1 | |
| SCHEMBL22650627 | 0.81 | CDK4 (0.39) | CDK9CDK1CDK4CCNB1CCND1 | |
| SCHEMBL22650620 | 0.79 | CDK2 (0.36) | SYKJAK2BRD4CDK9CDK1 | |
| SCHEMBL22650630 | 0.79 | CDK9 (0.35) | JAK2BRD4CDK9CDK1CCNB1 | |
| SCHEMBL22650781 | 0.75 | IKBKB (0.39) | SYKJAK2CDK1CDK4CCNB1 | |
| SCHEMBL22650514 | 0.75 | CDK4 (0.38) | CDK9CDK1CDK4CCNB1CCND1 | |
| SCHEMBL22650626 | 0.74 | CDK2 (0.39) | SYKJAK2CDK9CDK1CCNB1 | |
| SCHEMBL22650549 | 0.73 | ZAP70 (0.42) | CDK9CDK1CCNB1IKBKBCHUK | |
| SCHEMBL22650419 | 0.73 | JAK2 (0.38) | JAK2BRD4CDK9CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |